Malignant solitary fibrous tumors of the kidney are very rare.
Two tumors in one kidney is particularly rare and has not been previously reported. Due to the non-specific clinical symptoms, it is difficult but also very significant to give a definite diagnosis. Here, we report a case of two renal masses in one kidney. A 56-year-old man was admitted to our hospital complaining of shortness of breath, weakness, hyperhidrosis and intermittent hypoglycemia of 1-year duration without gross hematuria or lumbago. Imaging studies revealed two masses manifesting as inhomogeneous, with soft-tissue density and having no clear boundaries with the kidney. The patient was initially diagnosed with space-occupying lesions of the left kidney (with suspicions of renal cell carcinoma) and left radical nephrectomy was performed. Histologically, the tumors consisted of ovoid or spindle cells, and a hemangiopericytoma-like pattern and cellular atypia was observed in certain areas. Mitotic figures were more than 4 per 10 high-power fields. Immunohistochemically the tumor cells were positive for CD34, CD99 and vimentin. Accordingly, a diagnosis of malignant solitary fibrous tumor of the left kidney (low-grade malignance) was established. Postoperative follow-up of 10 months did not find tumor recurrence or metastasis and hypoglycemia was resolved with the removal of the tumors.
Written by:
Zhao G, Li G, Han R. Are you the author?
Department of Urology, Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin 300211, P.R. China.
Reference: Oncol Lett. 2012 Nov;4(5):993-995.
doi: 10.3892/ol.2012.858
PubMed Abstract
PMID: 23162638
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