A 63-year-old man presenting with a 7.2-cm right renal mass, an inferior vena cava tumor thrombus, and pulmonary metastases underwent renal mass biopsy that revealed clear cell renal cell carcinoma.
Temsirolimus (25 mg weekly) was given because of the extent of the disease and poor performance status, which resulted in a marked reduction in the tumor thrombus (from level III to level I) after 20 weeks of treatment. Subsequently, radical nephrectomy and tumor thrombectomy were carried out. Final pathological analysis confirmed the diagnosis of high-grade clear cell carcinoma (pT4N0M1). One year after initiation of temsirolimus therapy, the patient remained alive despite the presence of disease.
Written by:
Sano F, Makiyama K, Tatenuma T, Sakata R, Yamanaka H, Fusayasu S, Nakayama T, Nakaigawa N, Yao M, Kubota Y. Are you the author?
Department of Urology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.
Reference: Int J Urol. 2012 Nov 27. Epub ahead of print.
doi: 10.1111/iju.12012
PubMed Abstract
PMID: 23186017
UroToday.com Renal Cancer Section
