WHAT IS KNOWN AND OBJECTIVE: Posterior reversible encephalopathy syndrome (PRES) can be the result of acute hypertension, eclampsia, renal failure and the use of immunosuppressive or cytotoxic agents.
We report a case of PRES as a result of the use of pazopanib, a vascular endothelial growth factor inhibitor used for renal cell carcinoma (RCC).
CASE SUMMARY: A 76-year-old man treated with RCC develops PRES shortly after the initiation of pazopanib.
WHAT IS NEW AND CONCLUSION: There are no known reports of the association between PRES and pazopanib. We postulate that pazopanib can disrupt the normal endothelial function of the brain leading to the development of PRES.
Written by:
Asaithambi G, Peters BR, Hurliman E, Moran BP, Khan AS, Taylor RA. Are you the author?
Department of Neurology, University of Minnesota, Minneapolis, MN, USA.
Reference: J Clin Pharm Ther. 2013 Apr;38(2):175-6.
doi: 10.1111/jcpt.12031
PubMed Abstract
PMID: 23210935
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