BACKGROUND: Little is known on factors predicting sunitinib toxicity.
Recently, the condition of low muscle mass, named sarcopenia, was identified as a significant predictor of toxicity in metastatic renal cell cancer (mRCC) patients treated with sorafenib. We investigated whether sarcopenia could predict early dose-limiting toxicities (DLTs) occurrence in mRCC patients treated with sunitinib.
METHODS: Consecutive mRCC patients treated with sunitinib were retrospectively reviewed. A DLT was defined as any toxicity leading to dose reduction or treatment discontinuation. Body composition was evaluated using CT scan obtained within 1 month before treatment initiation.
RESULTS: Among 61 patients eligible for analysis, 52.5% were sarcopenic and 32.8% had both sarcopenia and a body mass index (BMI)< 25 kg m-2. Eighteen patients (29.5%) experienced a DLT during the first cycle. Sarcopenic patients with a BMI< 25 kg m-2 experienced more DLTs (P=0.01; odds ratio=4.1; 95% CI: (1.3-13.3)), more cumulative grade 2 or 3 toxicities (P=0.008), more grade 3 toxicities (P=0.04) and more acute vascular toxicities (P=0.009).
CONCLUSION: Patients with sarcopenia and a BMI< 25 kg m-2 experienced significantly more DLTs during the first cycle of treatment.
Written by:
Huillard O, Mir O, Peyromaure M, Tlemsani C, Giroux J, Boudou-Rouquette P, Ropert S, Delongchamps NB, Zerbib M, Goldwasser F. Are you the author?
Department of Medical Oncology, University Paris Descartes, Paris, France.
Reference: Br J Cancer. 2013 Mar 19;108(5):1034-41.
doi: 10.1038/bjc.2013.58
PubMed Abstract
PMID: 23462722
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