OBJECTIVE: To assess microvascular tumor invasion and other clinical and histological parameters as potential prognostic factors in surgically treated renal cell carcinoma.
MATERIALS AND METHODS: Surgical specimens from 238 consecutive patients who underwent radical or partial surgery between 1990 and 2006 were retrospectively evaluated. The series included clinically localized or metastatic renal cell carcinoma (pT1-4; N0-1; M0-1). Disease-free and cancer-specific survival assessments were the end points with median follow-up of 75 months (range 1-189 months). Variables studied included: age, sex, tumor size, TNM 2010 classification, Fuhrman grade, histological subtype and microvascular tumor invasion.
RESULTS: Microvascular tumor invasion was observed in 79 patients (33,2%) and was significantly associated with age (P= .010), tumor size (P= .000), Fuhrman grade (P= .000), pT stage 2010 (P= .000),N stage 2010 (P=.000) and M stage 2010 (P= .000). Multivariate analyses determined that sex, Fuhrman grade, pT stage 2010 and histological subtipe were independent prognostic factors of disease-free survival, while sex, Fuhrman grade, pT stage 2010, M stage 2010, histological subtype and microvascular invasion were prognostic factors for cancer-specific survival.
CONCLUSIONS: Our study shows that microvascular tumor invasion is an independent prognostic factor for cancer-specific survival in surgically treated patients with renal cell carcinoma.
Written by:
Santiago-Agredano B, Alvarez-Kindelán J, Font-Ugalde P, Blanca-Pedregosa A, López-Beltrán A, Requena-Tapia MJ. Are you the author?
Servicio de Urología, Unidad de Gestión Clínica de Urología, Hospital Universitario Reína Sofía, Córdoba, España.
Reference: Actas Urol Esp. 2013 Apr 23. pii: S0210-4806(12)00381-6.
doi: 10.1016/j.acuro.2012.07.008
PubMed Abstract
PMID: 23623182
Article in English, Spanish.
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