BACKGROUND: Due to economic constraints, cancer therapies are under close scrutiny by clinicians, pharmacists and payers alike.
There is no published pharmacoeconomic evidence guiding the choice of first-line therapy for advanced renal cell carcinoma (RCC) in the Spanish setting. We aimed to develop a model describing the natural history of RCC that can be used in healthcare decision-making. We particularly analyzed the budget impact associated with the introduction of pazopanib compared to sunitinib under the Spanish National Healthcare System (NHS) perspective.
METHODS: We developed a Markov model to estimate the future number of cases of advanced RCC (patients with favorable or intermediate risk) resulting either from initial diagnosis or disease progression after surgery. The model parameters were obtained from the literature. We assumed that patients would receive either pazopanib or sunitinib as first-line therapy until disease progression. Pharmacological costs and costs associated with the management of adverse events (AE) were considered. A univariate sensitivity analysis was undertaken in order to test the robustness of the results.
RESULTS: The model predicted an adult RCC prevalence of 7.5/100,000 (1-year), 20.7/100,000 (3-year) and 32.5/100,000 (5-year). These figures are very close to GLOBOCAN reported RCC prevalence estimates of 7.6/100,000, 20.2/100,000 and 31.1/100,000, respectively. The model predicts 1,591 advanced RCC patients with favorable or intermediate risk in Spain in 2013. Annual per patient pharmacological costs were [euro sign]32,365 and [euro sign]39,232 with pazopanib and sunitinib, respectively. Annual costs associated with the management of AE were [euro sign]662 and [euro sign]974, respectively. Overall annual per patient costs were [euro sign]7,179 (18%) lower with pazopanib compared to sunitinib. For every point increase in the percentage of patients treated with pazopanib, the NHS would save [euro sign]67,236. If all the 1,591 patients predicted were treated with pazopanib, the NHS would save [euro sign]6,723,622 in 2013. Results were robust according to the sensitivity analysis.
CONCLUSIONS: We developed a model that accurately reproduces the natural history of RCC and can be thus used in healthcare decision-making. When applied to the Spanish case, the introduction of pazopanib results in savings for the NHS, as a consequence of both reduced pharmacological costs and lower costs associated with the management of AE compared to sunitinib.
Written by:
Villa G, Hernández-Pastor LJ. Are you the author?
Departamento de Evaluación de Medicamentos y Gestión Sanitaria, GlaxoSmithKline España, Severo Ochoa, 2, 28760, Tres Cantos, Madrid, Spain.
Reference: BMC Cancer. 2013 Sep 2;13(1):399.
doi: 10.1186/1471-2407-13-399
PubMed Abstract
PMID: 24004638
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