OBJECTIVE: To describe the clinical outcome of surgical treatment of renal-cell carcinoma in patients with von Hippel-Lindau disease.
To analyze the clinical, demographic and histopathological characteristics.
MATERIAL AND METHODS: From a total of 468 patients with renal-cell carcinoma treated surgically at our institution from 1982 to 2010, a series of 8 with von Hippel-Lindau disease were identified. Relevant variables included tumor recurrence, surgical approach, recurrence rate and mid-term preserved renal function.
RESULTS: Eight patients with von Hippel-Lindau disease and renal cell carcinoma were identified; 7 were treated with nephron-sparing surgery and 1 with radical nephrectomy. During the follow-up of 89.3 ± 67.5 months, we found ipsilateral tumor recurrence in two patients and contralateral in another one. Mean survival time was 72 months in seven out of eight patients who also preserved normal renal function; one patient with uncontrolled diabetes died from complications of chronic kidney disease five years after surgery.
CONCLUSIONS: Nephron-sparing surgery offers acceptable oncologic and functional results for patients with renal cell carcinoma and Von Hippel-Lindau disease.
Written by:
Uscanga-Yépez J, Rodríguez-Covarrubias F, Morales J, Granados J, Gabilondo-Navarro F. Are you the author?
Departamento de Urología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.
Reference: Rev Invest Clin. 2013 Jul-Aug;65(4):318-22.
PubMed Abstract
PMID: 24304732
Article in Spanish.
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