OBJECTIVE: To report the results and oncological efficacy of laparoscopic radical nephrectomy (LRN) in patients with renal cell carcinoma with renal vein and inferior vena cava thrombus.
METHODS: We performed retrospective record review of 41 patients who underwent LRN along with venous thrombectomy at 2 Canadian centers from 2002 to 2012 by dedicated laparoscopic surgeons.
RESULTS: The mean age and body mass index of the 41 study patients (34 males and 7 female) were 64.4 years and 28.7 kg/m2, respectively. Median tumor size was 9.3 cm; 39 patients had renal vein thrombus, and 2 had inferior vena cava thrombus. Nine patients (22%) had metastatic disease to begin with and underwent laparoscopic cytoreductive nephrectomy. Median estimated blood loss, operative time, and length of stay were 100 mL (range, 50-400 mL), 134.5 minutes (range, 99-183 minutes), and 4 days (range, 4-6 days), respectively. There were 4 (9.7%) grade 2 complications. There was no intraoperative death. Mean duration of follow-up was 42 months (range, 6-107 months). Of 32 patients with localized disease, 4 (12.5%) died of progressive disease, 3 (9.3%) died of unrelated causes, and 3 patients (9.3%) were lost to follow-up. Twenty-two patients (68.7%) were alive at a mean follow-up of 47 months.
CONCLUSION: LRN and venous thrombectomy for advanced renal tumors with venous thrombus are safe procedures in experienced hands with significant laparoscopic skills. The short-term oncological data are encouraging and advocate the efficacy of this procedure in this subset of patients, although longer follow-up is required in larger number of patients to further define its role.
Written by:
Bansal RK, Tu HY, Drachenberg D, Shayegan B, Matsumoto E, Whelan JP, Kapoor A. Are you the author?
McMaster Institute of Urology, St. Joseph's Healthcare, McMaster University, Hamilton, Ontario, Canada; Section of Urology, Department of Surgery, University of Manitoba, Winnipeg, Manitoba, Canada.
Reference: Urology. 2014 Jan 8. pii: S0090-4295(13)01424-6.
doi: 10.1016/j.urology.2013.09.060
PubMed Abstract
PMID: 24411219
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