A 61-year-old man presented to our hospital with hypercalcemia and elevated C reactive protein (CRP).
Evaluation revealed renal cell carcinoma (RCC) with metastasis to lung, bone, and brain. He underwent partial resection of the right kidney and a left nephrectomy. Histopathologic findings of resected tumors were consistent with clear cell RCC. Whole-brain irradiation was performed for management of brain metastasis. Postoperatively, he was treated with molecularly targeted therapy using a mammalian target of rapamycin inhibitor. Approximately 14 months later, he suffered an episode of upper gastrointestinal bleeding with secondary anemia and melena. Upper gastrointestinal endoscopy revealed a distinctly protruding lesion in the gastric body. Biopsy of the gastric lesion showed metastatic clear cell RCC. He underwent partial gastrectomy. His postoperative course was uneventful. However, 4 months after surgery, he died from brain metastasis. Metastatic RCC to the stomach, although rare, should be suspected in any patient with a history of RCC who presents with gastrointestinal symptoms.
Written by:
Sakurai K, Muguruma K, Yamazoe S, Kimura K, Toyokawa T, Amano R, Kubo N, Tanaka H, Yashiro M, Ohira M, Hirakawa K. Are you the author?
Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan.
Reference: Int Surg. 2014 Jan-Feb;99(1):86-90.
doi: 10.9738/INTSURG-D-13-00115.1
PubMed Abstract
PMID: 24444276
UroToday.com Renal Cancer Section
