Ga somatostatin receptor PET/CT, currently the most sensitive imaging modality for well-differentiated neuroendocrine tumors, is based on the molecular imaging of somatostatin receptors (SSTRs) that are expressed in different tumor entities such as neuroendocrine neoplasms, lymphomas, meningiomas, or renal cell cancer (RCC).
Most neuroendocrine neoplasms show a high expression of SSTR subtypes 2A and 5, whereas the overexpression of SSTR2A in RCC is mainly seen in peritumoral vessels. Here we report a case with strongly SSTR-positive pancreatic lesions detected by Ga DOTATOC PET/CT, which histologically turned out to be ultralate metastases of a RCC.
Written by:
Peter L, Sänger J, Hommann M, Baum RP, Kaemmerer D. Are you the author?
Department of General and Visceral Surgery, Zentralklinik Bad Berka, ENETS Center of Excellence; Laboratory of Pathology and Cytology; and Department of Molecular Radiotherapy/Center for Molecular Imaging (PET/CT), Zentralklinik Bad Berka, ENETS Center of Excellence, Bad Berka, Germany.
Reference: Clin Nucl Med. 2014 Feb 20. Epub ahead of print.
PubMed Abstract
PMID: 24561680
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