Malignant renal angiomyolipoma without tuberous sclerosis - Abstract

A 68-year-old woman presented with abdominal pain, fatigue, anorexia and night sweats.

Imaging studies identified a vascular mass extending from the upper pole of the right kidney with anterior displacement to the abdominal midline, consistent with renal cell carcinoma. A radical nephrectomy and right pelvic lymph node dissection was performed. Pathology determined a grade 4 malignant epithelioid angiomyolipoma that invaded hilar and perinephric adipose tissue. Gross tumour was also present within the renal vein, sinus, pelvis, capsule and perinephric fat. The tumour was HMB-45 positive, supporting the diagnosis of a typical angiomyolipoma in association with the high-grade epithelioid tumour.

Written by:
Cusano A, Abarzua-Cabezas F, Meraney A.   Are you the author?
Department of Urology, Hartford Hospital, Hartford, Connecticut, USA.

Reference: BMJ Case Rep. 2014 Apr 30;2014. pii: bcr2014204285.
doi: 10.1136/bcr-2014-204285


PubMed Abstract
PMID: 24789163

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