Epidemiological studies link obesity, as measured by increased body mass index (BMI) to the incidence of renal cell carcinoma (RCC) as well as to the cancer-related mortality of RCC patients.
RCC is the third cancer most robustly associated with increased BMI. Understanding the role of the adipose tissue in renal carcinogenesis is therefore of major importance for the development of novel paradigms of RCC prevention and treatment. Here, we discuss the current knowledge on the impact of obesity on the development and progression of RCC as well as the role of adipose tissue-derived hormones (adipokines) in the conflict between growing tumors and the immune system.
Written by:
Gati A, Kouidhi S, Marrakchi R, El Gaaied A, Kourda N, Derouiche A, Chebil M, Caignard A, Perier A. Are you the author?
Laboratoire de Génétique; Immunologie et Pathologies Humaines; Département de Biologie; Faculté des Sciences de Tunis; Campus Universitaire; Université Tunis-el Manar; El Manar-Tunis, Tunisia; Service d'histopathologie; Hôpital Charles Nicolle; Tunis, Tunisia; Service d'Urologie; Hôpital Charles Nicolle; Tunis, Tunisia; Institut Cochin; INSERM U1016; CNRS UMR 8104; Université Paris Descartes; Paris, France.
Reference: Oncoimmunology. 2014 Jan 1;3(1):e27810.
PubMed Abstract
PMID: 24804162
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