The morphological features and immunohistochemical findings of two cases of clear cell renal cell carcinoma with extensive hemangioblastoma-like features are described.
To the best of our knowledge, this is the first description of such a pattern, the differential diagnosis being with renal hemangioblastoma, a rare tumor that could be considered a diffuse hemangioblastoma-like change in a clear cell renal cell tumor. Even though the clinical significance and therapeutic implications are not yet known, the hemangioblastoma-like pattern could have favorable prognostic significance based on the fact that the renal hemangioblastomas described so far have benign behavior.
Written by:
Montironi R, Lopez-Beltran A, Cheng L, Galosi AB, Montorsi F, Scarpelli M. Are you the author?
Section of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy; Unit of Anatomic Pathology, Department of Surgery, Faculty of Medicine, Cordoba, Spain; Fundação Champalimaud, Lisbon, Portugal; Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN, USA; Urology Division, Murri Hospital, Fermo, Italy; 5Department of Urology, University Vita-Salute, Scientific Institute H. San Raffaele, Milan, Italy.
Reference: Eur Urol. 2014 May 2. pii: S0302-2838(14)00403-5.
doi: 10.1016/j.eururo.2014.04.022
PubMed Abstract
PMID: 24821578
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