PURPOSE: An overview of the responses to some of the most frequently asked questions regarding axitinib administration and dosage modifications used in clinical practice are presented.
SUMMARY: Axitinib was approved for second-line treatment of advanced renal cell carcinoma by the Food and Drug Administration on January 27, 2012. Inquiries received over the first six months after the approval date were reviewed. A large number of questions were related to administration of axitinib in different patient populations or in patients with various comorbidities, such as its (1) use in patients unable to swallow oral medication or administration of axitinib via a nasogastric tube, (2) use in patients with renal or hepatic impairment, (3) central nervous system penetration and use in patients with brain metastases, (4) drug interactions, particularly with anticoagulants, and (5) dosage modifications. Responses to these inquiries were provided based on the published literature or from data on file from the manufacturer. The dosage of axitinib can be adjusted for use in patients with hepatic impairment or in patients who cannot otherwise tolerate the usual regimen. Patients taking concomitant warfarin can also take axitinib, and patients who cannot swallow oral medications can receive a liquid formulation of the drug, though its efficacy and comparability to the tablet formulation has not been tested.
CONCLUSION: Based on the published literature and company data on file, the axitinib dosage may be modified to accommodate patients with renal or hepatic impairment, who cannot swallow oral medication, are receiving concomitant warfarin, or who cannot otherwise tolerate the standard dosage regimen. For patients who cannot swallow, an oral suspension can be prepared because crushing axitinib is not recommended.
Written by:
Borst DL, Arruda LS, MacLean E, Pithavala YK, Morgado JE. Are you the author?
Regional Medical Research Specialists, U.S. Medical Affairs, Pfizer, New York; Oncology Medical Information, Pfizer, Collegeville, PA; U.S. Health Economics and Outcomes Research-Oncology, Pfizer, New York, NY; Clinical Pharmacology, Pfizer, San Diego, CA; Chemistry-Analytics, Pfizer, Groton, CT; Regional Medical Research Specialists, U.S. Medical Affairs, Pfizer, New York, NY; Oncology Medical Information, Pfizer, Collegeville, PA; U.S. Health Economics and Outcomes Research-Oncology, Pfizer, New York, NY; Clinical Pharmacology, Pfizer, San Diego, CA. James E; Chemistry-Analytics, Pfizer, Groton, CT.
Reference: Am J Health Syst Pharm. 2014 Jul 1;71(13):1092-6.
doi: 10.2146/ajhp130581
PubMed Abstract
PMID: 24939498
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