Renal cell cancer has been rarely reported as a cause of gastric or esophageal metastases.
They usually present with gastrointestinal bleeding and most cases have been managed surgically or endoscopically. We report the case of a 38-year-old man with a 4-year history of metastatic renal cell carcinoma admitted to the emergency room with melena and anemia. At endoscopy, three esophageal polypoid lesions (middle and distal thirds) and a 7 cm mass in the gastric fundus were identified. Biopsy revealed esophageal mucosa infiltrated by renal cell carcinoma. Radiotherapy was administered (30 Gy in 10 fractions), followed by pazopanib, with excellent tolerance and without new bleeding episodes. Computed tomography scan showed complete disappearance of the esophageal and fundic lesions at 3 months follow-up. Twenty-four months after being initiated on pazopanib, there is no radiological evidence of disease. This is the first reported case showing complete remission of gastric and esophageal metastases after treatment with radiotherapy and pazopanib.
Written by:
Cabezas-Camarero S, Puente J, Manzano A, Corona JA, González-Larriba JL, Bernal-Becerra I, Sotelo M, Díaz-Rubio E. Are you the author?
Departments of Medical Oncology, Radiation Oncology, Pathology Center affiliated to the "Red Temática de Investigación Cooperativa (RD12/0036/006)", Instituto Carlos III, Spanish Ministry of Economy and Competitivity, Hospital Clínico San Carlos, 28040 Madrid, Spain.
Reference: Anticancer Drugs. 2014 Jul 29. Epub ahead of print.
doi: 10.1097/CAD.0000000000000150
PubMed Abstract
PMID: 25075797