PURPOSE: The objective of this article is to summarize the knowledge as for the side effects related to axitinib in terms of incidence, etiology and symptoms for the effects requiring a specific management.
METHODS: This article follows upon the recommendations for the clinical practice, published in 2011, which detailed the management of secondary specific toxicities related to targeted therapies prescribed for the treatment of metastatic renal cell carcinoma with a focus on axitinib.
SYNTHESIS: Overall, the toxicity profile of axitinib is better the other tyrosine kinase inhibitors. The ENT side effects and polycythemia, which had not been initially described with other molecules, seem more frequent. Regarding management and follow-up of side effects with axitinib, as for the other targeted therapies used in metastatic renal carcinoma, there are no crucial changes since the recommendations of 2011.
CONCLUSION: The management of side effects remains similar to the recommendations published in 2011. Only preventive measures and management of ENT side effects and polycythemia must be integrated in new thesaurus.
Written by:
Albiges L, Izzedine H, Ederhy S, Robert C, Gravis G, Boyle H, Scotté F, Hartl D, Escudier B. Are you the author?
Institut Gustave-Roussy, Département d'oncologie médicale, 39, rue Camille-Desmoulins, 94805 Villejuif cedex, France; CHU Pitié-Salpêtrière, Service de néphrologie, 47-83, boulevard de l'Hôpital, 75651 Paris cedex 13, France; CHU Saint-Antoine, Service de cardiologie, 184, rue du Faubourg-Saint-Antoine, 75571 Paris cedex 12, France; Institut Gustave-Roussy, Service de dermatologie, 94805 Villejuif, France; Institut Paoli-Calmettes, Département d'oncologie médicale, 232, boulevard Sainte-Marguerite, 13273 Marseille cedex 9, France; Centre Léon-Bérard, Département d'oncologie médicale, 28, rue Laennec, 69373 Lyon, France; Hôpital européen Georges-Pompidou, Service d'oncologie médicale, 20, rue Leblanc, 75908 Paris cedex 15, France; Institut Gustave-Roussy, Département d'oto-rhino-laryngologie, 94805 Villejuif, France.
Reference: Bull Cancer. 2014 Oct;101(10):976-88.
doi: 10.1684/bdc.2014.2042
PubMed Abstract
PMID: 25373697
Article in French.