Background: Stereotactic ablative body radiotherapy (SABR) has been proposed as a definitive treatment for patients with inoperable primary renal cell carcinoma.
However, there is little documentation detailing the radiobiological effects of hypofractionated radiation on healthy renal tissue.
Findings: In this study we describe a methodology for assessment of regional change in renal function in response to single fraction SABR of 26Gy. In a patient with a solitary kidney, detailed follow-up of kidney function post-treatment was determined through 3-dimensional SPECT/CT imaging and 51Cr-EDTA measurements. Based on measurements of glomerular filtration rate, renal function declined rapidly by 34% at 3 months, plateaued at 43% loss at 12 months, with minimal further decrease to 49% of baseline by 18 months.
Conclusions: The pattern of renal functional change in 99mTc-DMSA uptake on SPECT/CT imaging correlates with dose delivered. This study demonstrates a dose effect relationship of SABR with loss of kidney function.
Written by:
Jackson P, Foroudi F, Pham D, Hofman MS, Hardcastle N, Callahan J, Kron T, Siva S. Are you the author?
Department of Physical Sciences, Peter MacCallum Cancer Centre, East Melbourne, VIC, Australia.
Reference: Radiat Oncol. 2014 Nov 26;9(1):253.
doi: 10.1186/s13014-014-0253-z
PubMed Abstract
PMID: 25424613