Outcome assessment for renal cell carcinoma is somewhat controversial.
Despite numerous studies, a very limited variety of features have been recognized as having prognostic significance in clinical practice. In this review, tumor features considered to be of importance in outcome prediction for surgically treated patients with the 3 most commonly encountered morphotypes of renal cell carcinoma (clear cell, papillary, and chromophobe renal cell carcinoma) are evaluated. In particular, we have focused upon histologic subtype, sarcomatoid and rhabdoid differentiation, TNM staging, primary tumor size, tumor grade, and the presence of histologic coagulative tumor necrosis. We have also examined the importance of these prognostic features in a variety of postoperative or outcome prediction models developed by several institutions.
Written by:
Lohse CM, Gupta S, Cheville JC. Are you the author?
Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota; Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 First St, Southwest Rochester, Minnesota 55905.
Reference: Semin Diagn Pathol. 2015 Mar;32(2):172-83.
doi: 10.1053/j.semdp.2015.02.008
PubMed Abstract
PMID: 25753528