To determine if partial nephrectomy (PN) confers a renal functional benefit compared to radical nephrectomy (RN) for clinical T2 renal masses (T2RM) when adjusting for tumor complexity characterized by the RENAL nephrometry score.
A 2-center study of 202 patients with T2RM undergoing RN (122) or PN (80) (median follow-up, 41. 5 months). RN and PN cohorts were subanalyzed according to RENAL sum as a categorical variable of
No significant differences existed between PN and RN for RENAL score. ΔeGFR was greater in RN (-19. 7) vs PN (-11. 9; P = . 006). De novo CKD was 40. 2% after RN vs 16. 3% after PN (P
RN is independently associated with decreased renal function compared to PN for T2RM with RENAL sum ≤10, but not >10, with larger relative decrease in eGFR for each decrease in RENAL sum. Further investigation is required to determine optimal candidates for PN in T2RM.
Urology. 2015 Jul 16 [Epub]
Ryan P Kopp, Michael A Liss, Reza Mehrazin, Song Wang, Hak J Lee, Ramzi Jabaji, Hossein S Mirheydar, Kyle Gillis, Nishant Patel, Kerrin L Palazzi, Jim Y Wan, Anthony L Patterson, Ithaar H Derweesh
Department of Urology, Moores Cancer Center, UC San Diego Health System, La Jolla, CA. , Department of Urology, Moores Cancer Center, UC San Diego Health System, La Jolla, CA. , Department of Urology, University of Tennessee Health Science Center, Memphis, TN. , Department of Urology, Moores Cancer Center, UC San Diego Health System, La Jolla, CA. , Department of Urology, Moores Cancer Center, UC San Diego Health System, La Jolla, CA. , Department of Urology, Moores Cancer Center, UC San Diego Health System, La Jolla, CA. , Department of Urology, Moores Cancer Center, UC San Diego Health System, La Jolla, CA. , Department of Urology, Moores Cancer Center, UC San Diego Health System, La Jolla, CA. , Department of Urology, Moores Cancer Center, UC San Diego Health System, La Jolla, CA. , Department of Urology, Moores Cancer Center, UC San Diego Health System, La Jolla, CA. , Department of Urology, University of Tennessee Health Science Center, Memphis, TN. , Department of Urology, University of Tennessee Health Science Center, Memphis, TN. , Department of Urology, Moores Cancer Center, UC San Diego Health System, La Jolla, CA.