Metastatic renal cell carcinoma (mRCC) prognostic models may be improved by incorporating treatment-induced toxicities.
In sunitinib-treated mRCC patients (N=770), baseline prognostic factors and treatment-induced toxicities (hypertension (systolic blood pressure ⩾140 mm Hg), neutropenia (grade ⩾2), thrombocytopenia (grade ⩾2), hand-foot syndrome (grade >0), and asthenia/fatigue (grade >0)) were analysed in multivariate analyses of progression-free survival (PFS) and overall survival (OS) end points.
On-treatment neutropenia and hypertension were associated with longer PFS (P=0. 0276 and P
On-treatment neutropenia and hypertension are independent biomarkers of sunitinib efficacy and may add prognostic accuracy to the IMDC model. British Journal of Cancer advance online publication 22 October 2015; doi:10. 1038/bjc. 2015. 368 www. bjcancer. com.
British journal of cancer. 2015 Oct 22 [Epub ahead of print]
Frede Donskov, M Dror Michaelson, Igor Puzanov, Mellar P Davis, Georg A Bjarnason, Robert J Motzer, David Goldstein, Xun Lin, Darrel P Cohen, Robin Wiltshire, Brian I Rini
Department of Oncology, Aarhus University Hospital, Norrebrogade 44, Aarhus C 8000, Denmark. , Massachusetts General Hospital Cancer Center, The Claire and John Bertucci Center for Genitourinary Cancers, 55 Fruit Street, Yawkey 7E, Boston, MA 02114, USA. , Division of Hematology-Oncology, Vanderbilt University Medical Center, 2220 Pierce Avenue, 777 Preston Research Building, Nashville, TN 37232-6307, USA. , Palliative Medicine and Supportive Oncology Services, Division of Solid Tumor, Cleveland Clinic Taussig Cancer Institute, 9500 Euclid Avenue, Desk R35, Cleveland, OH 44195, USA. , Division of Medical Oncology, Sunnybrook Odette Cancer Centre, 2075 Bayview Avenue, Toronto, ON M4N 3M5, Canada. , Department of Medicine, Genitourinary Oncology Service, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA. , Department of Medical Oncology, Prince of Wales Hospital, Randwick, NSW 2031, Australia. , Pfizer Oncology, 10646 Science Center Drive, La Jolla, CA 92121, USA. , Pfizer Oncology, 10646 Science Center Drive, La Jolla, CA 92121, USA. , Pfizer Oncology, Walton Oaks, Dorking Road, Walton-on-the-Hill, Tadworth, Surrey KT20 7NS, UK. , Cleveland Clinic Taussig Cancer Institute, Glickman Urological Institute, 9500 Euclid Avenue, Desk R35, Cleveland, OH 44195, USA.