Purpose. To compare the differences of CT characteristics between renal cell carcinomas (RCCs) associated with Xp11.2 translocation/TFE3 gene fusions (Xp11.2 RCCs) and papillary cell renal cell carcinomas (PRCCs).
Methods. CT images and clinical records of 64 patients (25 Xp11. 2 RCCs, 15 type 1 and 24 type 2 PRCCs) were analyzed and compared retrospectively. Results. Xp11. 2 RCC more frequently affected young (30. 7 ± 8. 7 years) women (16/25, 64%) with gross hematuria (12/25, 48%), while PRCC more frequently involved middle-aged (54. 8 ± 11. 1 years) men (28/39, 71. 8%) asymptomatically. Xp11. 2 RCC tended to be heterogeneous density with some showing circular calcification. Lesion sizes of Xp11. 2 RCC (5. 4 ± 2. 2 cm) and type 2 PRCC (5. 7 ± 2. 5 cm) were significantly larger than that of type 1 PRCC (3. 8 ± 1. 8 cm). Xp11. 2 RCC contained more cystic components (22/25, 88%) than type 1 PRCC (all solid) and type 2 PRCC (9/24, 36. 0%). Type 1 PRCC (13/15, 86. 7%) and Xp11. 2 RCC (21/25, 84. 0%) showed more clear boundary than type 2 PRCC (12/24, 50. 0%). Conclusion. CT features including diameter, boundary, attenuation, nature, and circular calcification of the tumor, combined with demographic information and symptoms, may be useful to differentiate Xp11. 2 RCC from different subtypes of PRCC.
BioMed research international. 2015 Nov 09 [Epub]
Jian He, Kefeng Zhou, Bin Zhu, Gutian Zhang, Xiaogong Li, Hongqian Guo, Weidong Gan, Zhengyang Zhou, Tian Liu
Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. , Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. , Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. , Department of Urology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. , Department of Urology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. , Department of Urology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. , Department of Urology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. , Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China. , Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA.