Although the preoperative aspects and dimensions used for the PADUA scoring system were successfully applied in macroscopic clinical practice for renal tumor, the relevant molecular genetic basis remained unclear.
To uncover meaningful correlations between the genetic aberrations and radiological features, we enrolled 112 patients with clear cell renal cell carcinoma (ccRCC) whose clinicopathological data, genomics data and CT data were obtained from The Cancer Genome Atlas (TCGA) and The Cancer Imaging Archive (TCIA). Overall PADUA score and several radiological features included in the PADUA system were assigned for each ccRCC. Despite having observed no significant association between the gene mutation frequency and the overall PADUA score, correlations between gene mutations and a few radiological features (tumor rim location and tumor size) were identified. A significant association between rim location and miRNA molecular subtypes was also observed. Survival analysis revealed that tumor size > 7 cm was significantly associated with poor survival. In addition, Gene Set Enrichment Analysis (GSEA) on mRNA expression revealed that the high PADUA score was related to numerous cancer-related networks, especially epithelial to mesenchymal transition (EMT) related pathways. This preliminary analysis of ccRCC revealed meaningful correlations between PADUA anatomical features and molecular basis including genomic aberrations and molecular subtypes.
Oncotarget. 2016 Feb 02 [Epub ahead of print]
Hui Zhu, Haoyan Chen, Zhiqian Lin, Guohai Shi, Xiaozhu Lin, Zhiyuan Wu, Xia Zhang, Xi Zhang
Department of Radiology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. , State Key Laboratory for Oncogenes and Related Genes, Division of Gastroenterology and Hepatology, Renji Hospital, Shanghai Institute for Digestive Diseases, Shanghai Jiao-Tong University School of Medicine, Shanghai 200001, China. , Department of Radiology, Renji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200001, China. , Department of Urology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China. , Department of Radiology, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China. , Department of Radiology, Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China. , Department of Oncology, East Hospital, Tongji University School of Medicine, Shanghai 200120, China. , Department of Physiology and Neurobiology, University of Connecticut, Storrs, CT 06269-3156, USA.