The objective of this study was to evaluate whether renal cell carcinoma (RCC) risk-associated single nucleotide polymorphisms (SNPs) could reflect the individual inherited risks of RCC. A total of 346 RCC patients and 1,130 controls were recruited in this case-control study. Genetic scores were calculated for each individual based on the odds ratios and frequencies of risk-associated SNPs. Four SNPs were significantly associated with RCC in Chinese population. Two genetic score models were established, genetic score 1 (rs10054504, rs7023329 and rs718314) and genetic score 2 (rs10054504, rs7023329 and rs1049380). For genetic score 1, the individual likelihood of RCC with low (<0.8), medium (0.8-1.2) and high (≥1.2) genetic score 1 was 15.61%, 22.25% and 33.92% respectively (P-trend=6.88×10-7). For genetic score 2, individual with low (<0.8), medium (0.8-1.2) and high (≥1.2) genetic score 2 would have likelihood of RCC as 14.39%, 24.54% and 36.48%, respectively (P-trend=1.27×10-10). The area under the receiver operating curve (AUC) of genetic score 1 was 0.626, and AUC of genetic score 2 was 0.658. We concluded that genetic score can reveal personal risk and inherited risk of RCC, especially when family history is not available.
Oncotarget. 2016 Feb 23 [Epub ahead of print]
Yishuo Wu, Ning Zhang, Kaiwen Li, Haitao Chen, Xiaolin Lin, Yang Yu, Yuancheng Gou, Jiangang Hou, Deke Jiang, Rong Na, Xiang Wang, Qiang Ding, Jianfeng Xu
Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China., Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China., Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yet-sen University, Guangdong, PR China., State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, PR China., Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, PR China., Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China., Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China., Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China., State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, PR China., Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China., Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China., Department of Urology, Huashan Hospital, Fudan University, Shanghai, PR China., Fudan Institute of Urology, Huashan Hospital, Fudan University, Shanghai, PR China.