The aim of this study was to investigate the influence of age at diagnosis on tumor characteristics and cancer-specific survival (CSS) in renal cell carcinoma (RCC).
Data of patients who underwent radical or partial nephrectomy for renal tumor between 2003 and 2011 at multiple institutions were collected. Patients were divided into two groups according to age at diagnosis: 20-39 years and 40-79 years. To adjust for potential baseline confounders, propensity score matching was performed.
All included data showed that young RCC patients presented with renal tumors that had a more favorable histological subtype, were localized, smaller in size, and had a lower Fuhrman nuclear grade. The 5 year CSS rates were 95.5% and 90.5% in the young and old patient groups, respectively (log rank p = 0.019). After matching on the propensity score, the two groups with RCC had 302 patients each. Because the groups were matched on covariates, there were no significant differences in the pathological proportion, tumor size, Fuhrman nuclear grade and clinical T stage. The 5 year CSS rates were 95.5% and 94.7% in the young and old patient groups, respectively (log rank p = 0.184).
After adjusting for potential biases, there was no significant difference in prognosis between young and old patients with RCC.
Scandinavian journal of urology. 2016 Jul 14 [Epub ahead of print]
Jeong Ho Kim, Yong Hyun Park, Yong June Kim, Seok Ho Kang, Seok Soo Byun, Sung-Hoo Hong
a Department of Urology , Dongnam Institute of Radiological & Medical Sciences, Cancer Center , Busan , Republic of Korea ;, b Department of Urology , Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea , Seoul , Republic of Korea ;, c Department of Urology , Chungbuk National University College of Medicine , Cheongju , Republic of Korea ;, d Department of Urology , Korea University School of Medicine , Seoul , Republic of Korea ;, e Department of Urology , Seoul National University Bundang Hospital , Seongnam , Republic of Korea., b Department of Urology , Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea , Seoul , Republic of Korea ;