To validate plasma fibrinogen and serum cholesterol levels as prognostic factors for patients with renal cell carcinoma (RCC) and explore the prognostic value of their combination.
Medical data for 1360 RCC patients after nephrectomy were collected. X-tile software was used to determine the cut off values. The association between clinicopathological factors and fibrinogen and cholesterol levels was determined and factors predicting survival was examined by multivariate analysis.
The median follow-up was 67 months (interquartile range 36-74 months). On univariate and multivariate analysis, both preoperative plasma fibrinogen and serum cholesterol were independent prognostic factors of cancer-free survival (CSS) and progression free survival (PFS). By combining the 2 factors, we developed a novel index, fibrinogen-cholesterol (FC) score and found it to have better prognostic accuracy than the 2 factors alone. FC was an independent prognostic factor for both CSS (FC score=1: HR=3.207, 95% CI=1.775-5.793; FC score =2: HR= 5.516, 95% CI= 2.891-10.527) and PFS (FC score=1: HR= 2.178, 95% CI=1.545-3.071; FC score=2: HR= 3.709, 95% CI= 2.355-5.840).
Preoperative plasma fibrinogen and serum cholesterol levels are both independent prognostic factors for CSS and PFS in RCC patients after nephrectomy. A novel indicator, FC score, could be a novel preoperative prognostic index in RCC.
Journal of endourology. 2017 Jan 25 [Epub ahead of print]
Ding Peng, Zhisong He, Xuesong Li, Qi Tang, Lei Zhang, Kaiwei Yang, Xiaoteng Yu, Cuijian Zhang, Liqun Zhou
Peking University First Hospital, 26447, Urology , 8 , Xishiku Street , Xicheng District , Beijing, China , 100034 ; ., Peking University First Hospital, Department of Urology, Beijing, China ; ., Peking University First Hospital, Urology, Beijing, China ; ., Peking University First Hospital, 26447, Urology, Beijing, Beijing, China ; ., Peking University First Hospital, Urology, Beijing, China ; ., Peking University First Hospital, 26447, Urology, Beijing, Beijing, China ; ., Peking University First Hospital, 26447, Urology, Beijing, Beijing, China ; ., Peking University First Hospital; Institute of Urology, Peking University; National Urological Cancer Center, Urology , No.8 Xishiku Str. West Dist. , Beijing, Beijing, China , 100034 ; ., Peking University First Hospital, Urology, Beijing, China ; .