There are insufficient predictive markers for renal cell carcinoma (RCC).
A total of 308 metastatic RCC patients were analyzed retrospectively.
The increased hemoglobin (Hb) group had significantly higher progression-free survival and overall survival (OS) compared with the decreased Hb group at 11. 5 versus 6.35 months (p < .001) and 21.0 versus 11.36 months (p < .001) respectively. The 1- and 3-year OS rates were higher in the Hb increased group, i.e., 84% versus 64% and 52% versus 35% respectively.
The present study showed that increased Hb levels after tyrosine kinase inhibitor therapy could be a predictive marker of RCC.
Cancer investigation. 2017 Mar 23 [Epub ahead of print]
Cemil Bilir, İbrahim Yıldız, Ahmet Bilici, Mahmut Ucar, Veli Berk, Yaşar Yıldız, Ozan Yazıcı, Gökşen İnanç İmamoğlu, Nuri Karadurmuş, Kezban Nur Pilancı, Erkan Arpacı, Özgür Tanrıverdi, Ebru Karcı, Süleyman Temiz, Erdinc Nayır, Esin Oktay, Pınar Dal, İbrahim Petekkaya, Ceyhun Varım, Hakan Cinemre
a Department of Internal Medicine and Medical Oncology , Sakarya University School of Medicine , Sakarya , Turkey., b Acıbadem Atakent Hospital , Istanbul , Turkey., c Department of Medical Oncology , Medipol University School of Medicine , Istanbul , Turkey., d Department of Medical Oncology , Erciyes University School of Medicine , Kayseri , Turkey., e Department of Medical Oncology , Izmir Katip Çelebi University School of Medicine , Izmir , Turkey., f Department of Medical Oncology , Ankara Numune Teaching and Education Hospital , Ankara , Turkey., g Department of Medical Oncology , Dışkapı Teaching and Education Hospital , Ankara , Turkey., h Department of Medical Oncology , Gulhane School of Medicine , Ankara , Turkey., i Department of Medical Oncology , Haseki Teaching and Education Hospital , Istanbul , Turkey., j Department of Medical Oncology , Bülent Ecevit University School of Medicine , Zonguldak , Turkey., k Department of Medical Oncology , Mugla Sıtkı Koçman University School of Medicine , Mugla , Turkey., l Department of Medical Oncology , Ankara University School of Medicine , Ankara , Turkey., m Acıbadem Kocaeli Hospital , Kocaeli , Turkey., n Department of Medical Oncology , Kahramanmaras Necip Fazil City Hospital , Kahramanmaras , Turkey., o Department of Medical Oncology , Adnan Menderes University Faculty of Medicine , Aydin , Turkey., p Department of Medical Oncology , Eskisehir Osman Gazi University School of Medicine , Eskişehir , Turkey., q Department of Medical Oncology , Kent Hospital , Mugla , Turkey.