Despite the progress in the quality of multiphasic CT and MRI scans, it is still difficult to fully characterize a solid kidney lesion. Approximately 10% of all solid renal tumours turn out to be oncocytomas. In actual clinical practice, this is verified only following unnecessary surgery or a renal biopsy/ablation. The objective of our pilot study examines whether (99m)Tc-sestamibi SPECT/CT can play a crucial role in the characterization of solid renal neoplasms and the differentiation of oncocytomas from renal cell carcinomas. The study included 27 patients identified with 31 solid renal lesions. All patients were discussed in a multidisciplinary conference, and a decision for surgery or biopsy was taken. Prior to invasive procedures, patients underwent a SPECT/CT with (99m)Tc-sestamibi. Visual evaluation was performed, and any focal (99m)Tc-sestamibi uptake detected on SPECT in the localisation of tumour was considered as positive.
Eleven out of 12 oncocytomas (91.6%) displayed positive uptake of (99m)Tc-sestamibi. Three hybrid tumours (mixed-type oncocytoma and chromophobe renal cancer) were positive on SPECT/CT. One papillary renal cell carcinoma had a slight uptake of (99m)Tc-sestamibi. The remaining 11 renal cell carcinomas were sestamibi negative.
Differentiation of benign renal oncocytomas from renal cell carcinomas seems very promising on (99m)Tc-sestamibi SPECT/CT examination. Additional supplement to visual evaluation, i.e. quantitative tools, should be sought for an accurate estimate of biological behaviour and hence a secure diagnosis.
EJNMMI research. 2017 Mar 29 [Epub]
Antonios Tzortzakakis, Ove Gustafsson, Mattias Karlsson, Linnea Ekström-Ehn, Rammin Ghaffarpour, Rimma Axelsson
Radiology Department, Division of Medical Imaging and Technology, Karolinska University Hospital, C1-46, SE-141 86, Huddinge, Stockholm, Sweden. ., Division of Urology, Karolinska University Hospital, Huddinge, Sweden., Medical Radiation Physics and Nuclear Medicine, Functional Unit of Nuclear Medicine, Karolinska University Hospital, Huddinge, Sweden., Division of Radiology, Department for Clinical Science Intervention and Technology (CLINTEC), Karolinska Institute and Medical Physics and Nuclear Medicine, BOF Karolinska University Hospital, Huddinge, Sweden.