The purpose of the present study is to investigate the association between the polymorphisms in AXIN1 with susceptibility to clear cell renal cell carcinoma (ccRCC).
A total of 284 ccRCC patients and 439 healthy volunteers were enrolled. Totally three tag single nucleotide polymorphisms in AXIN1 gene were genotyped using PCR & restriction fragment length polymorphism.
Significantly increased ccRCC risk was observed to be associated with the CT/CC genotypes of rs1805105 and AA genotype of rs12921862. Patients carrying the rs1805105 CT genotype had a 1.92-fold increased risk to developing clinical stage III and IV cancer.
Our results suggested the rs1805105 CT/CC genotypes and rs12921862 AA genotype may relate to ccRCC development.
Biomarkers in medicine. 2017 Oct 20 [Epub ahead of print]
Yan Pu, Xuhua Mi, Peng Chen, Bin Zhou, Peng Zhang, Yanyun Wang, Yaping Song, Lin Zhang
Department of Forensic Biology, West China School of Basic sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, P.R. China., Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R. China., Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu, 211166, P.R. China., Laboratory of Molecular Translational Medicine, West China Institute of Women & Children's Health, Key Laboratory of Obstetric & Gynecologic & Pediatric Diseases & Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R. China., Department of Urology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, P.R. China.