Germ cell tumor with malignant transformation is extremely rare. We present a case of testicular primitive neuroectodermal tumor with multiple metastases that was effectively managed by surgery, irradiation, and second-line chemotherapy.
A 22-year-old man was diagnosed as having teratoma including primitive neuroectodermal tumor with lymph node and multiple bone metastases. Five months afterwards the first-line therapy, his skull metastasis recurred. Vincristine, doxorubicin, and cyclophosphamide therapy followed by vincristine, actinomycin D, and cyclophosphamide therapy was given as second-line chemotherapy. Computed tomography revealed no disease progression 3 months after the treatments.
Metastatic primitive neuroectodermal tumor may be successfully managed by multidisciplinary cancer treatment.
IJU case reports. 2022 Mar 26*** epublish ***
Takuya Takasawa, Tomonori Minagawa, Takahisa Domen, Toshirou Fukushima, Yu Fujii, Mai Iwaya, Tomonobu Koizumi, Teruyuki Ogawa, Osamu Ishizuka
Department of Urology Shinshu University School of Medicine Matsumoto Japan., Department of Hematology and Medical Oncology Shinshu University School of Medicine Matsumoto Japan., Department of Neurosurgery Shinshu University School of Medicine Matsumoto Japan., Department of Laboratory Medicine Shinshu University Hospital Matsumoto Japan.