To summarize the results of available studies for investigating the role of neutrophil to lymphocyte ratio (NLR) in testicular cancer (tCa).
The search was conducted on PubMed, Scopus, and Web of Science up to November 21, 2021. Finally, a total of 31 studies were included in this review.
NLR was higher in tCa patients compared to healthy controls and benign testis pathologies, and decreased significantly after orchiectomy. An elevated NLR predicts poor prognosis, advanced stage, presence of nodal or distant metastases, contralateral tumor development, lower time-to-cancer specific death, worse OS, and poorer response to chemotherapy. However, NLR could not differentiate between seminomas and non-seminomatous tCa.
NLR has a significant diagnostic and prognostic value in tCa.
Exploration of targeted anti-tumor therapy. 2024 Sep 19 [Epub]
Shirin Sarejloo, Saghar Babadi, Shokoufeh Khanzadeh, Amirhossein Salimi, Alec Clark, Dinyar Khazaeli, Monireh Khanzadeh, Arshin Ghaedi, Brandon Lucke-Wold
Cardiovascular Research Center, Shiraz University of Medical Sciences, Shiraz 767545, Iran., Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz 868765, Iran., Student Research Committee, Tabriz University of Medical Sciences, Tabriz 585658, Iran., Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd 876576, Iran., University of Central Florida College of Medicine, Orlando, FL 32608, USA., Urology Department, Imam Khomeini Hospital, Ahvaz 687667, Iran., Geriatric & Gerontology Department, Medical School, Tehran University of Medical and Health Sciences, Tehran 865476, Iran., Student Research Committee, School of Medicine, Shiraz University of Medical Sciences, Shiraz 767545, Iran., Department of Neurosurgery, University of Florida, Gainesville, FL 32608, USA.