Testicular germ cell tumors (TGCTs) are a heterogeneous group of tumors that occur more commonly in adolescent and adult men. Depending on their age of onset, biological behavior, morphologic characteristics, and molecular alterations, they are divided into different subtypes. A common alteration in malignant TGCTs is the formation of an isochromosome 12p, leading to copy number alterations in pluripotency and cell cycle regulating genes. Genetic predispositions and somatic alterations rarely occur in TGCTs. This article gives an overview on the current knowledge of genomic alterations that play a role in the predisposition, development, diagnosis, and treatment of TGCTs.
Surgical pathology clinics. 2024 Sep 25 [Epub]
Alexander Fichtner, Stefanie Zschäbitz, Daniel Nettersheim, Felix Bremmer
Institute of Pathology, University Medical Center Göttingen, Robert-Koch-Str. 40, Göttingen 37075, Germany., Department of Medical Oncology, National Centre for Tumor Diseases (NCT), University Hospital Heidelberg, Heidelberg, Germany., Department of Urology, Urological Research Laboratory, Translational UroOncology, Medical Faculty and University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany; Center for Integrated Oncology Aachen, Bonn, Cologne, Düsseldorf (CIO ABCD)., Institute of Pathology, University Medical Center Göttingen, Robert-Koch-Str. 40, Göttingen 37075, Germany. Electronic address: .