Lynch Syndrome in Japanese Patients with Upper Urinary Tract Carcinoma - Expert Commentary
The researchers found that MSI and IHC results were concordant. They found that four patients had high microsatellite instability and loss of at least one MMR protein by IHC. Three of the four patients were genetically proven to have Lynch syndrome. The fourth patient had features that were highly suggestive for Lynch syndrome based on personal cancer history but did not undergo genetic testing. The prevalence of LS was 1.8% (3/16). The study found an association between microsatellite instability high-level/mismatch repair loss and age < 70 years (P = 0.04), previous history or synchronous diagnosis of colorectal cancer (P < 0.01) and fulfillment of any of the revised Bethesda criteria guidelines (P < 0.01) and ureteric tumor location (P = 0.052) in univariate analysis.
While the majority of UTUCs are sporadic, this study highlights the known association between UTUC and LS. Developing screening and early-prevention strategies for LS patients who are at risk of developing UTUC and their families is an area of active investigation.
Written by: Bishoy M. Faltas, MD, Director of Bladder Cancer Research, Englander Institute for Precision Medicine, Weill Cornell Medicine, New York City, New York
Reference:
1. Ito, Tetsuya, Koji Kono, Hidetaka Eguchi, Yasushi Okazaki, Gou Yamamoto, Tetsuhiko Tachikawa, Kiwamu Akagi et al. "Prevalence of Lynch syndrome among patients with upper urinary tract carcinoma in a Japanese hospital-based population." Japanese journal of clinical oncology (2019).
Read the Abstract