To compare procedure burden, oncologic, surgical and renal-function outcomes between patients with low-grade upper urothelial cancer (UTUC) who were referred for either radical management (RM) or kidney-sparing endoscopic management (EM).
We retrospectively reviewed data of all patients treated for UTUC at our tertiary medical center between 2000 and 2018 and selected patients diagnosed with unilateral low-grade UTUC.
24 patients were treated with EM and 37 with RM. Surgical and oncologic risk factors were similar between the arms except for tumor size. Mean follow-up was 4.9±3.4 years. The 5-year overall-survival rate was 85% with EM and 84% with RM (p=0.707). Metastasis-free and cancer-specific survival were also similar (p=0.994, p=0.960). End-of-follow-up average glomerular filtration rates were 58.7±21.5 and 49.2±22.1 mL/min/1.73 m2, respectively (p=0.12). 92% of patients managed endoscopically had local recurrences, with an average of 3.2 recurrences per patient. Four (17%) patients underwent salvage radical nephroureterectomy. Procedure burden was higher with EM, having 6.5±4.4 operations and 344±272 minutes under anesthesia compared with 1.9±0.4 operations (p<0.0001) and 213±84 minutes under anesthesia (p=0.031) with RM. Cost-of-care analysis revealed higher costs for EM in both private and publicly funded medical insurance plans.
Patients undergoing endoscopic management had an 83% chance of preserving their kidney and an 81% chance of 5-year metastasis-free survival at a cost of 6.5±4.4 operations during a mean follow-up of 4.9±3.4 years. Our findings support EM for low-grade UTUC as a valid option from oncological aspects but highlight the associated costs.
Urology. 2021 Sep 15 [Epub ahead of print]
Chen Shenhar, Yotam Veredgorn, Shir Bulis, Tzach Aviv, Abd Elhalim Darawsha, Ron Gilad, Jack Baniel, Yaron Ehrlich, David Lifshitz
Department of Urology, Rabin Medical Center, Petah Tikva, Israel, affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. Electronic address: ., Department of Urology, Rabin Medical Center, Petah Tikva, Israel, affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel; Department of Urology, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel, affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. Electronic address: ., Department of Urology, Rabin Medical Center, Petah Tikva, Israel, affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. Electronic address: ., Department of Urology, Rabin Medical Center, Petah Tikva, Israel, affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. Electronic address: ., Department of Urology, Rabin Medical Center, Petah Tikva, Israel, affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. Electronic address: ., Department of Urology, Rabin Medical Center, Petah Tikva, Israel, affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. Electronic address: ., Department of Urology, Rabin Medical Center, Petah Tikva, Israel, affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. Electronic address: ., Department of Urology, Rabin Medical Center, Petah Tikva, Israel, affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. Electronic address: ., Department of Urology, Rabin Medical Center, Petah Tikva, Israel, affiliated with the Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel. Electronic address: .