UGN-101 can be used for chemoablation of low-grade upper tract urothelial carcinoma (UTUC). The gel can be administered via a retrograde route through a ureteral catheter or an antegrade route via a nephrostomy tube.
To report outcomes of UGN-101 by route of administration.
We performed a retrospective review of 132 patients from 15 institutions who were treated with UGN-101 for low-grade UTUC via retrograde versus antegrade administration.
Survival outcomes are reported per patient. Treatment, complications, and recurrence outcomes are reported per renal unit. Statistical analysis was performed for primary endpoints of oncological response and ureteral stricture occurrence.
A total of 136 renal units were evaluated, comprising 78 retrograde and 58 antegrade instillations. Median follow-up was 7.4 mo. There were 120 cases (91%) of biopsy-proven low-grade UTUC. Tumors were in the renal pelvis alone in 89 cases (65%), in the ureter alone in 12 cases (9%), and in both in 35 cases (26%). Seventy-six patients (56%) had residual disease before UGN-101 treatment. Chemoablation with UGN-101 was used in 50/78 (64%) retrograde cases and 26/58 (45%) antegrade cases. A complete response according to inspection and cytology was achieved in 31 (48%) retrograde and 30 (60%) antegrade renal units (p = 0.1). Clavien grade 3 ureteral stricture occurred in 21 retrograde cases (32%) and only six (12%) antegrade cases (p < 0.01). Limitations include treatment bias, as patients in the antegrade group were more likely to undergo endoscopic mechanical ablation before UGN-101 instillation.
These preliminary results show a significantly lower rate of stricture occurrence with antegrade administration of UGN-101, with no apparent impact on oncological efficacy.
We compared results for two different delivery routes for the drug UGN-101 for treatment of cancer in the upper urinary tract. For the antegrade route, a tube is inserted through the skin into the kidney. For the retrograde route, a catheter is inserted past the bladder into the upper urinary tract. Our results show a lower rate of narrowing of the ureter (the tube draining urine from the kidney into the bladder) using the antegrade route, with no difference in cancer control.
European urology focus. 2023 May 30 [Epub ahead of print]
Jennifer Linehan, Josh Gottlieb, Solomon L Woldu, Craig Labbate, Kyle Rose, Wade Sexton, Hristos Kaimakliotis, Joseph Jacob, Rian Dickstein, Alan Nieder, Marc Bjurlin, Mitchell Humphreys, Saum Ghodoussipor, Marcus Quek, Michael O'Donnell, Brian H Eisner, Adam S Feldman, Surena F Matin, Yair Lotan, Katie S Murray
Providence Specialty Medical Group, Santa Monica, CA, USA., University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address: ., University of Texas Southwestern Medical Center, Dallas, TX, USA., University of Texas MD Anderson Cancer Center, Houston, TX, USA., Moffitt Cancer Center, Tampa, FL, USA., Indiana University Medical Center, Indianapolis, IN, USA., State University of New York Upstate Medical Center, Syracuse, NY, USA., University of Maryland Medical Center, Baltimore Washington Medical Center, Glen Burnie, MD, USA; Chesapeake Urology, Baltimore, MD, USA., Mount Sinai Medical Center, Miami Beach, FL, USA., University of North Carolina Medical Center, Chapel Hill, NC, USA., Mayo Clinic Cancer Center, Phoenix, AZ, USA., Rutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA., Loyola University Medical Center, Maywood, IL, USA., University of Iowa Health Care, Iowa City, IA, USA., Massachusetts General Hospital, Boston, MA, USA., NYU Langone Health, New York, NY, USA.
PubMed http://www.ncbi.nlm.nih.gov/pubmed/37263827
Read an Expert Commentary by Bishoy Faltas, MD