11C-sarcosine Articles

Articles

First Human Application of Novel PET Tracer for Prostate Cancer
New tracer holds promise of monitoring targeted treatment of various cancers

In the featured translational article in the August issue of The Journal of Nuclear Medicine, researchers at the University of Michigan demonstrate the potential of a new PET tracer, Carbon-11 labeled sarcosine (¹¹C-sarcosine), for imaging prostate cancer, and set the stage for its possible use in monitoring other cancers.

Published August 10, 2017
Preclinical Evaluation of 11C-Sarcosine as a Substrate of Proton-Coupled Amino Acid Transporters and First Human Application in Prostate Cancer.
Sarcosine is a known substrate of proton-coupled amino acid transporters (PATs), which are overexpressed in selected tissues and solid tumors. Sarcosine, an N-methyl derivative of the amino acid glycine and a metabolic product of choline, plays an important role for prostate cancer aggressiveness and progression.

Published August 10, 2017