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- Oliver Sartor and Kambiz Rahbar discuss the RaLu study examining the safety and efficacy of sequential radiopharmaceutical treatments in metastatic castration-resistant prostate cancer. The discussion highlights how lutetium-PSMA therapy can be safely administered following radium treatment, with outcomes consistent across different treatment sequences and timing intervals. They examine how these...
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- Neal Shores joins Alicia Morgans in conversation to discuss the RALU study. RALU is a retrospective analysis that sought to evaluate the safety and clinical outcomes of sequential radium-223/177Lu-PSMA therapy in patients with metastatic castration-resistant prostate cancer (mCRPC). The study found that patients tolerated Lutetium-177 well, and PSA and alkaline phosphatase declines were observed....
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- Kambiz Rahbar joins Alicia Morgans to discuss a post hoc analysis of the RALU study, which looks at the time interval between radium and lutetium-PSMA treatment and its effect on the safety and effectiveness of lutetium treatment in patients with metastatic castration-resistant prostate cancer. This analysis aimed to assess the safety and survival outcomes with lutetium when treatment began within...
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- In this conversation, Alicia Morgans and Oliver Sartor discuss the safety and efficacy data from the RALU study where patients with metastatic castration-resistant prostate cancer received lutetium-177-prostate-specific membrane antigen (PSMA) with prior radium-223 treatment. The RAdium LUtetium (RALU) study evaluated the feasibility of sequential alpha and beta emitter use in patients with bone-p...
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- In this conversation, Alicia Morgans, Phillip Koo, and Neal Shore evaluate a patient case of a 78-year-old man who in 2017, imaging demonstrated numerous bone mets and the patient was subsequently diagnosed with metastatic castration-resistant prostate cancer (CRPC) with symptomatic bone metastases. Drs Shore, Koo, and Morgans talk through treatment options for this patient and the consideration o...
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- In this conversation, Alicia Morgans, Phillip Koo, and Neal Shore evaluate a patient case of a 63-year-old man who was diagnosed with de novo metastatic prostate cancer in January 2020. He was initially treated for metastatic hormone-sensitive prostate cancer with enzalutamide plus ADT. He presents again now with progression of bone-only metastatic disease. Drs Shore, Koo, and Morgans talk through...
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- In this conversation, Pedro Barata and Alicia Morgans discuss the sequencing of radiopharmaceuticals in metastatic castration-resistant prostate cancer. Reviewing several trials in this treatment landscape, including data from ALSYMPCA, VISION, REASSURE, WARMTH, and more recently, the RALU study Pedro Barata presents several different treatment scenarios where we can fit radium-223, among all of t...
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- In this UroToday Journal Club Chris Wallis and Zach Klaassen highlight a Journal of Nuclear Medicine publication entitled Safety and Survival Outcomes of Lutetium-177-Prostate-Specific Membrane Antigen Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer with prior Radium-223 treatment: The RALU Study . The RAdium LUtetium (RALU) study evaluated the feasibility of sequential al...
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