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- Ruchika Talwar interviews Justin Ziemba about a significant development in kidney stone disease advocacy and research. Dr. Ziemba announces the creation of the Kidney Stone Collaborative (KSC), a new nonprofit organization dedicated to improving research and advocacy for kidney stone patients. He explains that this initiative has been months in the making, involving scientific experts, patient adv...
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- Zach Klaassen discusses the EvoPAR-Prostate 01 trial with Neeraj Agarwal. The trial examines a new PARP inhibitor combined with ARPI in metastatic hormone-sensitive prostate cancer, both in biomarker-positive and -negative populations. Dr. Agarwal explains the rationale based on preclinical data and previous trials like PROpel and TALAPRO-2, showing efficacy in HRR mutation-positive patients and p...
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- Diane Newman interviews Jill Peters-Gee about her comprehensive book on interstitial cystitis (IC). Dr. Peters-Gee discusses her motivation for writing the book due to outdated resources and new information from the MAPP Network. She explains the terminology confusion between IC and bladder pain syndromes (BPS) and emphasizes the need for phenotyping to tailor treatments. They discuss the importan...
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- Diane Newman interviews Ariana Smith about the newly released AUA/SUFU Overactive Bladder Guidelines. Dr. Smith, who co-chaired the guidelines, emphasizes the shift from a stepwise therapy approach to a patient-centered menu of treatment options. This new guideline encourages shared decision-making, allowing patients to consider all treatments upfront based on their personal values and goals. It i...
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- Diane Newman interviews Siobhan Sutcliffe about her research on the Preventive Lower Urinary Tract Symptoms (PLUS) Consortium, specifically focusing on the Rise for Health Study. Dr. Sutcliffe explains that the study aims to understand factors promoting bladder health and preventing lower urinary tract symptoms (LUTS) in women. The cohort study, started in May 2022, includes women aged 18 and olde...
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- Diane Newman interviews Siobhan Sutcliffe about a project funded as part of the White House Moonshot Initiative. This project aims to gather more data to support PSA-based risk-stratified screening for prostate cancer. By using a man's PSA value, the research seeks to determine whether he might develop clinically significant prostate cancer that could potentially shorten his lifespan. The study in...
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- Ruchika Talwar interviews Justin Dubin about his use of social media to combat urology-related misinformation. Dr. Dubin emphasizes the importance of educating patients not just in the clinic but also online, where misinformation is rampant. Dr. Dubin co-created the "Man Up" podcast to destigmatize men's health issues and provide accurate, doctor-driven information. He advises urologists to be sin...
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- Sam Chang interviews Oscar Rodriguez-Faba about the SSANTROP trial. This phase II trial assesses the efficacy of combining sacituzumab govitecan, a monoclonal antibody targeting the Trop-2 receptor, with the PD-1 inhibitor sasanlimab in BCG-unresponsive non-muscle-invasive bladder cancer. The trial aims to provide a systemic therapy alternative to radical cystectomy, with a sample size goal of 120...
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- Ruchika Talwar interviews Nathan Grunewald discussing the critical issue of workforce shortages in rural America. Dr. Grunewald explains that while 20% of the US population lives in rural areas, only 10% of urologists serve these regions, many of whom are nearing retirement. This shortage leads to significant access issues, as patients often lack timely preventive care and face more severe health...
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- Ashish Kamat engages with Kamal Pohar and Kelly Bree on bladder cancer surveillance. They discuss the ongoing debate about the utility of various urinary markers in monitoring bladder cancer. Dr. Pohar mentions his reliance on cytology, while Dr. Bree adds that she uses cytology and occasionally UroVysion FISH for atypical cases, and also blue light cystoscopy despite its challenges. They both hig...
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