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- Sam Chang and Jeffrey Holzbeierlein discuss the comparative effectiveness of neoadjuvant chemotherapy for bladder cancer, as well as for upper urinary tract urothelial carcinoma. Dr. Holzbeierlein goes into depth on the background of neoadjuvant treatment for these diseases, as well as a look at the POUT trial. They also discuss future projects and exciting new studies. Biographies: Jeffrey Holzbe...
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- In this discussion with Sam Chang on the prevention of bladder recurrence, Aditya Bagrodia starts off with a case study of a 69-year-old female in generally good health, presents with hematuria, well-controlled diabetes, hypertension, remote history of smoking, and importantly, no history of upper tract urothelial cancer in the family or other Lynch syndrome-associated malignancies. Drs. Bagrodia...
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- Low-risk non-muscle-invasive bladder cancer (NMIBC) is associated with extremely low rates of progression and cancer-specific mortality; however, patients with low-risk NMIBC may often receive non-guideline-recommended and potentially costly surveillance testing and treatment. The objective of this study was to describe current surveillance and treatment practices, cancer outcomes, and costs of ca...
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- Ashish Kamat is joined by Laura Bukavina to discuss her work on the Microbiome of Bladder Cancer. Currently, we have little knowledge about the microbiome and bladder cancer. The research being done at Fox Chase and Case Western is comparing the beta diversity of bladder cancer patients compared to healthy controls to help think of ways to modulate the microbiome to improve the treatment of patien...
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- Kristen Scarpato, Svetlana Avulova, and Anne Schuckman join Sima Porten in this conversation on the realities of diagnosis and treatment of bladder cancer in women. They start by evaluating a patient case to highlight some women who present with bladder cancer and discuss what's most important when we talk about caring for these patients and how to improve care. Biographies: Sima P. Porten, MD, MP...
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- Ashish Kamat engages with Shievon Smith and Jacqueline Duncan to explore bladder cancer care from a nursing perspective. Dr. Duncan, specializing in diagnostics, advocates for a 28-day window to complete all scans and investigations. Dr. Smith focuses on treatment, discussing challenges in muscle-invasive bladder cancer care and the need for comprehensive approaches that consider fertility and men...
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- Ashish Kamat, Ananya Choudhury, and Nick James discuss trimodal therapy, or radiotherapy, for bladder preservation in patients with bladder cancer. Dr. Choudhury touches on how to differentiate treatment between moving towards cystectomy and deciding on radiotherapy. They also discuss differing radiotherapy schedules and how those differences can affect patients. Biographies: Ananya Choudhury, MA,...
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- Fernando Korkes discusses the groundbreaking work of Korkes and his team in Brazil. Addressing the issue of high mortality rates for muscle-invasive bladder cancer in developing countries, Dr. Korkes elaborates on the implementation of a multidisciplinary clinical practice called the CABEM project. The initiative involved a comprehensive team of medical professionals, led by Dr. Korkes and initiat...
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- Ashish Kamat engages Phillip Abbosh to explore cutting-edge research in bladder cancer. Dr. Abbosh highlights the ongoing RETAIN trial, which examines the safety and feasibility of avoiding cystectomy for patients with muscle-invasive bladder cancer who achieve a complete pathologic response post-neoadjuvant chemotherapy. The trial has enrolled 78 subjects and is awaiting mature data. Alongside, D...
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- Ekaterina Laukhtina and Ashish Kamat discuss urethral recurrence after radical cystectomy. Dr. Laukhtina goes into depth on using urethroscopy to diagnose urethral recurrence as well as when urethrectomy may be useful highlighting a systematic review and meta-analysis assessing the incidence and risk factors of urethral recurrence as well as summarizing data on survival outcomes in patients with u...
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