Prostate Cancer Biopsy Sampling: Challenges in Grade Group 1 Classification "Discussion" - Lawrence True
July 24, 2024
At the CAncer or Not Cancer: Evaluating and Reconsidering GG1 prostate cancer (CANCER-GG1?) Symposium, Lawrence True addresses the sampling issue in prostate cancer diagnosis, focusing specifically on biopsy results.
Biographies:
Lawrence True, MD, Pathologist, University of Washington, Seattle, WA
Biographies:
Lawrence True, MD, Pathologist, University of Washington, Seattle, WA
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Read the Full Video Transcript
Lawrence True: Yeah, so my thoughts are really based on the sampling issue and... I hear us talking about two things: prostate cancer, the radical prostate, and the biopsy. So this is really focused on the biopsy, and that is the third one here. This is from Lisa Newcomb, who manages our Canary Active Surveillance project. I asked her how often Grade Group 1 cancer is followed by progression in subsequent biopsies, or actually in the prostatectomy. Here you have the data that she sent: six positive nodes, six regional mets, nine distant mets. 21 patients out of about, I think it's now, what, 2,000-
2,000 or so. And then the second is that I asked her how often there's a second biopsy that's Grade Group 1 after. Could you increase the frequency with which you can say with confidence, the cancer, the Grade Group 1, and basically, you can't. And again, this is just focused on biopsies.
Lawrence True: Yeah, so my thoughts are really based on the sampling issue and... I hear us talking about two things: prostate cancer, the radical prostate, and the biopsy. So this is really focused on the biopsy, and that is the third one here. This is from Lisa Newcomb, who manages our Canary Active Surveillance project. I asked her how often Grade Group 1 cancer is followed by progression in subsequent biopsies, or actually in the prostatectomy. Here you have the data that she sent: six positive nodes, six regional mets, nine distant mets. 21 patients out of about, I think it's now, what, 2,000-
2,000 or so. And then the second is that I asked her how often there's a second biopsy that's Grade Group 1 after. Could you increase the frequency with which you can say with confidence, the cancer, the Grade Group 1, and basically, you can't. And again, this is just focused on biopsies.