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- Naomi Haas discusses the PROSPER trial, a study exploring perioperative nivolumab in high-risk renal cell carcinoma (RCC). The trial, which included both clear cell and non-clear cell histologies, aimed to assess whether priming the immune system preoperatively could improve outcomes. Despite initial optimism, the trial did not show a significant improvement in recurrence-free survival. Dr. Haas h...
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- Rana McKay and Sumanta (Monty) Pal join Zach Klaassen in discussing the Southern California Genitourinary (GU) Cancer Research Forum, a program aimed at uniting healthcare professionals in Southern California to coordinate research and patient care in GU cancers. The program highlights include discussions on kidney cancer, bladder cancer, and prostate cancer, integrating patient advocates and show...
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- The Randomized Phase II Stereotactic Ablative Radiation Therapy (SABR) for Metastatic Unresected Renal Cell Carcinoma (RCC) Receiving Immunotherapy (SAMURAI) trial compares standard immunotherapy to immunotherapy combined with radiation for patients not suited for surgery. It's an open-label trial, meaning participants and doctors know the treatments. After treatment, patients are closely monitore...
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- The RadiCaL trial is comparing the effectiveness of cabozantinib alone versus cabozantinib combined with radium-223 in metastatic renal cell cancer patients. This phase II trial investigates if the addition of radium-223 to the standard treatment, cabozantinib, improves outcomes in patients with bone metastases. Radium-223 is a radioactive drug that can target cancer cells directly while minimizin...
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- Rana McKay joins Alicia Morgans to discuss the RadiCaL trial, a study looking at metastatic kidney cancer and the use of radium in that population. The trial is a phase II trial, taking patients with renal cell carcinoma (RCC) with bone metastases and randomizing them 1:1 to receive radium with cabozantinib versus cabozantinib alone. The primary endpoint of RadiCaL is a reduction in symptomatic sk...
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- Principal investigator Tian Zhang joins Alicia Morgans to discuss the recent progress of the currently enrolling PDIGREE (Alliance A031704) trial. PDIGREE: An Adaptive Phase III Trial of PD-Inhibitor Nivolumab and Ipilimumab with VEGF TKI Cabozantinib in Metastatic Untreated Renal Cell Cancer (Alliance A031704) has been open since May of 2019 and now has nearly 300 patients enrolled, many of whom...
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- Potentially practice-changing study sponsored by the National Cancer Institute — A discussion with Rana McKay, MD, principal investigator. Radium-223 (223Ra) is an alpha particle-emitting radioactive agent that received Federal Drug Administration (FDA) approval in 2013 to treat patients with castration-resistant prostate cancer, symptomatic bone metastases, and no known visceral metastatic diseas...
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- PDIGREE is a novel adaptive frontline immunotherapy study which upon completion will help answer many important questions regarding treatment duration, when to combine VEGF therapy with IO therapy, and which patients benefit most from IO-VEGF combination upfront vs. sequential therapy. This trial is actively enrolling patients at all National Clinical Trials Network (NCTN) study sites. The primary...
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