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- Bone strengthening agents such as bisphosphonates or the RANKL-targeting antibody denosumab reduced the bone loss associated with androgen deprivation therapy (ADT) and prevent skeletal-related events in castration resistant prostate cancer (CRPC). The use of these agents is recommended in CRPC by many guidelines. The randomized phase III EORTC-1333-GUCG also known as the PEACE-III trial, compares...
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- In conversation with Alicia Morgans, Philip Koo discusses data from a phase II trial that randomized patients to receive radium-223 and sipuleucel-T or sipuleucel-T alone. Dr. Koo explains that patients who received the combination saw a better PSA response, providing evidence for the continued exploration of the combination of radiation and immunotherapy. Biographies: Phillip J. Koo, MD , FACS Di...
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- Michael Morris joins Alicia Morgans to discuss the new agents in development in the field of radiopharmaceuticals in advanced prostate cancer. Historically, much of the research has revolved around bone-targeted radiopharmaceuticals such as radium-223, however, Dr. Morris reviews the development of tumor-directed radiopharmaceuticals that are currently coming into clinical trials. The new therapie...
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- Matthew Smith shares his thoughts on the importance of bone health in the prostate cancer patient population. Osteoporotic or fragility fractures are common due to the age of the patient and long-term androgen deprivation therapy. Fractures have a great impact on patient mortality, mobility, independence, and overall quality of life. Dr. Smith addresses questions regarding bone density measurement...
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- Neal Shore joins Alicia Morgans in a discussion on the optimal timing to use radium-223 (Xofigo®) in metastatic castration-resistant prostate cancer (mCRPC). Together they discuss the window of opportunity for administering radium-223 and what we have learned from the ALSYMPCA and ERA-223 trials. Dr. Shore recaps how radium-223 is being used prior to docetaxel and how it is being layered with an a...
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- Neal Shore and Bertrand Tombal discuss the importance of bone health agents, particularly in patients receiving castrate-resistant prostate cancer agents. Highlights of their conversation include the use of antiresorptive therapy to reduce the risk of skeletal-related events in men with bone mCRPC and decreased fracture rate by mandating bone-protecting agents in the EORTC 1333/PEACE III trial. Bi...
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- At the Advanced Prostate Cancer Consensus Conference (APCCC 2019), Joe O'Sullivan joins Phillip Koo to discuss the onco-geriatric population, why it is referred to as a ticking time bomb, and the unique challenges it presents to the community. Biographies: Joe M. O'Sullivan, MD, FRCPI, FFRRSCI, FRCR, Professor of Radiation Oncology, Queen's University Belfast, Consultant Oncologist, Northern Irela...
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- Alicia Morgans and Fred Saad have a discussion on bone health in prostate cancer patients, an issue for men with advanced prostate cancer and an important topic to keep at the forefront of care. Even though men are living longer, bone metastases increases mortality and impair a person's independence. Fred and Alicia tackle approaching this in your patients, specifically in the metastatic castratio...
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- Oliver Sartor presented the impact and use of radium-223 during the Bone and Bone Metastases Session at the Advanced Prostate Cancer Consensus Conference (APCCC 2019). Dr. Sartor explains how Radium-223 first gained prominence with the reporting of the ALSYMPCA trial in 2013 which led to the FDA approval of radium-223 in the United States for patients with bone mCRPC without visceral metastases hi...
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- Chris Parker presents on the utilization of antiresorptive therapy to reduce skeletal-related events (SRE) risk in men with bone metastatic castration-resistant prostate cancer (mCRPC) at the Advanced Prostate Cancer Consensus Conference (APCCC 2019). Dr. Parker's presentation was part of a debate featured during the Bone and Bone Metastases Session. He summarized the evidence base in 2002 after t...
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