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- In this Journal Club video presentation, Christopher Wallis, MD, PhD, and Zachary Klaassen, MD describe a Clinical Genitourinary Cancer publication Treatment Patterns and Outcomes in Patients With Metastatic Castration-resistant Prostate Cancer in a Real-world Clinical Practice Setting in the United States. The primary objective of this analysis is to describe real-world treatment patterns, includ...
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- In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen discuss the recently published article in the Lancet Oncology, "Stereotactic ablative body radiotherapy in patients with oligometastatic cancers: A prospective, registry-based, single-arm, observational, evaluation study." Patients with oligometastatic disease have a more favorable prognosis than those with widespread metastati...
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- In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen discuss an analysis of risk, racial disparity, and outcomes among United States patients with cancer and COVID-19 infections. In this case-control study, patients with cancer were at significantly increased risk for COVID-19 infection, which was further exacerbated among African Americans, highlighting the need to protect and m...
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- In this Journal Club, Christopher Wallis and Zachary Klaassen review the September 2020 publication The Lancet Oncology: Durvalumab Alone and Durvalumab plus Tremelimumab Versus Chemotherapy in Previously Untreated Patients with Unresectable, Locally Advanced or Metastatic Urothelial Carcinoma (DANUBE): A Randomised, Open-Label, Multicentre, Phase 3 Trial. DANUBE was conducted at 224 academic rese...
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- After long-term follow-up, Nivolumab Plus Ipilimumab continues to demonstrate durable efficacy benefits vs sunitinib, with manageable safety. Nivolumab plus ipilimumab (NIVO+IPI) combination immunotherapy was the first to demonstrate superiority over sunitinib (SUN) in the first-line treatment of patients with advanced renal cell carcinoma (aRCC). NIVO+IPI is currently approved for clinical use in...
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- The optimal timing of radiotherapy after radical prostatectomy for prostate cancer is uncertain. In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen discuss the RADICALS-RT trial Lancet Oncology publication looking at the timing of radiotherapy following radical prostatectomy which aimed to compare the efficacy and safety of adjuvant radiotherapy versus an observation policy wit...
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- Male-carriers of BRCA1/2 gene mutations have an increased risk of prostate cancer (PCa) with a more aggressive phenotype. Current screening-guidelines suggest the use of prostate-specific antigen (PSA) only among BRCA2 carriers. Female carriers have extensive guidelines that include imaging. The study objective was to test the prevalence of prostate cancer among BRCA carriers and examine screening...
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- Rucaparib was evaluated as a treatment for men with metastatic castration-resistant prostate cancer (mCRPC) associated with a BRCA gene alteration who had received prior taxane and androgen receptor–directed therapy. In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen discuss the clinical rationale which led to the exploration of PARP inhibitors in men with advanced prostate can...
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- Christopher Wallis and Zachary Klaassen provide an in-depth review of the Lancet Oncology publication "Adjuvant radiotherapy versus early salvage radiotherapy following radical prostatectomy (TROG 08.03/ANZUP RAVES): a randomised, controlled, phase 3, non-inferiority trial" in this UroToday Journal Club. Biographies: Christopher J.D. Wallis, MD, Ph.D., Instructor in Urology, Vanderbilt University...
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- There are a number of trials looking at the role of adjuvant radiotherapy in prostate cancer. It is unclear whether adjuvant or early salvage radiotherapy following radical prostatectomy is more appropriate for men who present with localized or locally advanced prostate cancer. In this Journal Club, Christopher Wallis, MD, Ph.D., and Zachary Klaassen, MD, MSc discuss the recent publication from th...
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