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- In this presentation, Robert Bristow speaks on the concept of local radiotherapy to the primary tumor in the metastatic prostate cancer setting at the Advanced Prostate Cancer Consensus Conference (APCCC) 2019. Dr. Bristow's presentation covers the concept of oligometastatic disease, the rationale for treating the primary tumor, and the future role of metastases-directed therapy including differen...
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- Robert Reiter presented the definitions and concepts of oligometastatic prostate cancer at the Advanced Prostate Cancer Consensus Conference (APCCC 2019). With improved imaging, this definition has become important from a terminology and treatment standpoint. Dr. Reiter highlights several potential pathways of oligometastasis from the primary tumor and highlights two important clinical questions r...
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- Kim Chi presented an update on the utilization of PARP inhibitors during the Management of Castration-Resistant Prostate Cancer (CRPC) session at the 2019 Advanced Prostate Cancer Consensus Conference (APCCC). Leading his presentation with the most recent positive phase III results from Lynparza® (olaparib), the only PARP inhibitor with positive phase III results in four different cancer types. He...
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- Eric Small presents on the treatment of oligometastatic and oligoprogressive castration-resistant prostate cancer (CRPC) at the Advanced Prostate Cancer Consensus Conference (APCCC 2019). Dr. Small argues that instead of oligoprogressive CRPC, two other definitions should be used: (i) synchronous oligometastatic CRPC – metastases are synchronous with the emergence of ADT resistance, and (ii) metac...
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- Piet Ost discusses the treatment of oligorecurrent prostate cancer after local therapy at the Advanced Prostate Cancer Consensus Conference (APCCC 2019). Currently, there is no consensus definition for oligometastatic disease although a consensus working definition is being developed by the EORTC-ESTRO group. Highlighting findings from his own trial, Dr. Ost also frames these two main points durin...
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- Michael Morris presented de novo oligometastatic prostate cancer at the Advanced Prostate Cancer Consensus Conference (APCCC 2019) during the session on PSA Recurrence After Radical Local Therapy and Oligometastatic Prostate Cancer. His presentation highlights trials that support level 1 evidence that AR-directed therapy improves overall survival in M1 disease, trials that have assessed metastasis...
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- Charles Drake presented on immunotherapy for metastatic castration-resistant prostate cancer (mCRPC) during the Management of Castration-resistant Prostate Cancer (CRPC) session at the Advanced Prostate Cancer Consensus Conference (APCCC) 2019. He reviews several immunotherapy trials including the first major successful trial in immunotherapy for prostate cancer, the IMPACT trial in 2010 which led...
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- Fernando Maluf joins Charles Ryan to discuss the data from the first Prostate Cancer Global Consensus Conference for Developing Countries. This was a tremendous achievement in which more than a hundred physicians from all over the world, particularly from developing countries in Latin America, Africa, and the Middle East participated. Physicians that participated included several specialties: urol...
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- Alicia Morgans and Brad McGregor discuss rare genitourinary histologies and the efforts to find treatment options for populations not always included in clinical trials. Most clinical trials are developed and designed for the most common subtypes, not including atypical variant histologies often found in bladder and prostate cancers. Given the tumor agnostic approach of immunotherapy, Brad and his...
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- Thomas Steuber spoke on the role of surgery in the setting of metastatic prostate cancer at the Advanced Prostate Cancer Consensus Conference (APCCC 2019). He highlights the advantages of surgical removal of the primary tumor, the effects of surgery on cancer-specific survival and overall survival compared with no local treatment in the setting of de novo metastatic prostate cancer, and prospectiv...
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