Overactive Bladder VL

COURAGE Trial: Vibegron for BPH Patients with Persistent OAB Symptoms - David Staskin

Details
David Staskin discusses the COURAGE trial, a phase three study evaluating the efficacy of Vibegron, a beta-3 adrenergic receptor agonist, in men with BPH and persistent OAB symptoms despite alpha-blocker treatment. The study demonstrates significant improvements in various urinary symptoms, including micturitions, urgency episodes, and nocturia. Dr. Staskin highlights the drug's favorable safety p...

Optimizing Overactive Bladder Treatment: Phenazopyridine's Cost-Effective Approach - Anjali Kapur

Details
Anjali Kapur discusses a cost analysis comparing oral Phenazopyridine (Pyridium) to intravesical lidocaine for pain control during Botox injections for overactive bladder. The study finds that using Pyridium is less costly, saving about $98 per visit and potentially $24 million annually if widely adopted. Dr. Kapur highlights the high prevalence of overactive bladder and the increasing use of Boto...

Oxybutynin-Associated Cognitive Impairment: Evidence and Implications for Overactive Bladder Treatment - Beyond the Abstract

Details
Anticholinergic medications have long been mainstays of overactive bladder (OAB) treatment. Oxybutynin, a first-generation anticholinergic, still accounts for more than half of all OAB medication prescriptions, despite associations with impaired memory and cognition, as well as mounting evidence that it may increase the risk of incident dementia. Biographies: Michael Chancellor, MD, Corewell Healt...

Emerging Technologies in Urology: A Glimpse Into Tibial Nerve Stimulation for Bladder Dysfunction Treatment - Diane Newman & Howard Goldman

Details
In this discussion, Diane Newman, talks with Howard Goldman about advances in neuromodulation technology for patients with lower urinary tract dysfunction, overactive bladder, and urinary incontinence. Dr. Goldman highlights the potential of implantable tibial nerve stimulation devices, particularly a small device developed by BlueWind Medical. The device, placed next to the tibial nerve, is power...

Revolutionizing Urodynamics: Uromonitor's Comfortable, Real-Life Bladder Pressure Tracking - Diane Newman & Howard Goldman

Details
Diane Newman engages in a discussion with Howard Goldman on the Uromonitor, a non-invasive urodynamic device designed to measure bladder pressures in a more comfortable, natural setting. This innovative device, developed in partnership with Bright Urology and the Cleveland Clinic, is placed in the bladder and allows patients to move freely without external catheters. The Uromonitor, with its "Holt...

Phase 2a Trial Results: Promising Gene Therapy for Overactive Bladder - URO-902 Safety and Efficacy Evaluation - Kenneth Peters

Details
Ken Peters joins Diane Newman to present the results of a Phase 2a trial evaluating the safety and efficacy of URO-902, an investigational gene therapy for overactive bladder. URO-902 is a plasma vector that expresses the alpha subunit of the human BK channel, which reduces bladder overactivity and leads to detrusor relaxation. The trial included women between 40 and 70 years old with urgency freq...

Interpretation of the Meaningfulness of Symptom Reduction with Vibegron in Patients with Overactive Bladder: Analyses from EMPOWUR - Beyond the Abstract

Details
Patient perception of meaningful reductions in bothersome symptoms of overactive bladder (OAB) is lacking. In the phase 3 EMPOWUR trial, vibegron significantly reduced the average daily number of micturitions, urgency episodes, and urge urinary incontinence (UUI) episodes vs placebo. This analysis assessed the meaningfulness of reductions in clinical endpoints observed in EMPOWUR using the patient...

Mechanistic Pathway Through Which Saphenous Nerve Stimulation Can Modulate Bladder Function - Paul Yoo

Details
Joining Diane Newman is Paul Yoo to discuss his presentation from this year's SUFU annual meeting on saphenous nerve stimulation. In this particular study, Dr. Yoo's lab was interested in the mechanistic pathway through which saphenous nerve stimulation can modulate bladder function, and how this could be translated to patients with overactive bladder. Biographies: Paul Yoo, Ph.D., PEng, Associate...

Developing A Novel Neuromodulation Therapy for Treating Overactive Bladder - Anne Agur

Details
Diane Newman is joined by Anne Agur to share how they collect data to develop novel models of the human saphenous nerve. These novel models of the human saphenous nerve will be used to develop neuromodulation therapy approaches, both an engineering finite element approach, and for clinicians to look at electrode placement. The 3D data provides a very precise in situ map of the distribution of the...

The Effects of Vibegron on Ambulatory Blood Pressure in Patients With Overactive Bladder - Michael A. Weber

Details
Diane Newman is joined by Michael Weber discussing a novel medication for the treatment of overactive bladder and a study Dr Weber presented at the AUA 2021 Annual Meeting. Vibegron, a beta-3 receptor agonist is used for the treatment of overactive bladder. Adults with overactive bladder in the age range, 40 to 75, were randomized to treatment either with Vibegron 75 milligrams per day or placebo....