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- Zach Klaassen interviews Ahmed Ghazi about his work in robotic simulation. Dr. Ghazi shares his journey from laparoscopic surgery in Europe to robotic surgery in the US, emphasizing the need for realistic surgical training tools. He developed 3D-printed, hydrogel organs that simulate bleeding, enhancing training realism. At Hopkins, Dr. Ghazi established SLICE (Surgical Learning and Innovation Cen...
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- Oliver Sartor discusses his approach to treating low-volume metastatic prostate. Dr. Sartor emphasizes the importance of molecular imaging, particularly PSMA PET, to define low-volume and oligometastatic disease accurately. He advocates for a "total therapy" approach, combining androgen deprivation, novel hormones, and targeted radiation, including SBRT for metastatic sites and pelvic radiation. D...
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- Michael Morris discusses optimal imaging standards for metastatic hormone-sensitive prostate cancer. He explains that conventional imaging methods like PSA tracking are insufficient for monitoring disease progression in the era of advanced androgen receptor signaling inhibitors (ARSIs). Dr. Morris emphasizes the need for regular imaging, recommending scans every six to twelve months to detect radi...
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- Zach Klaassen discusses the EvoPAR-Prostate 01 trial with Neeraj Agarwal. The trial examines a new PARP inhibitor combined with ARPI in metastatic hormone-sensitive prostate cancer, both in biomarker-positive and -negative populations. Dr. Agarwal explains the rationale based on preclinical data and previous trials like PROpel and TALAPRO-2, showing efficacy in HRR mutation-positive patients and p...
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- Andrea Miyahira engages with Jelani Zarif regarding his team’s paper elucidating the metabolic reprogramming of tumor-associated macrophages utilizing the potent glutamine antagonist JHU083. Their dialogue explores the intricate mechanisms underpinning glutamine metabolism within tumor cells and macrophages, unveiling the transformative impact of JHU083 on macrophage functionality. Dr. Zarif artic...
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- Diane Newman interviews Siobhan Sutcliffe about a project funded as part of the White House Moonshot Initiative. This project aims to gather more data to support PSA-based risk-stratified screening for prostate cancer. By using a man's PSA value, the research seeks to determine whether he might develop clinically significant prostate cancer that could potentially shorten his lifespan. The study in...
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- Andrea Miyahira discusses a study on noninvasive detection of neuroendocrine prostate cancer with Himisha Beltran and Francesca Demichelis. Their collaborative paper, published in Cancer Discovery, introduces a targeted cell-free DNA methylation panel called NEMO (Neuroendocrine Monitoring). This panel aims to distinguish neuroendocrine prostate cancer from adenocarcinoma using DNA methylation pat...
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- Zach Klaassen speaks with Todd Morgan about innovative approaches in the management of prostate cancer post-prostatectomy. Dr. Morgan presents compelling new data on the prostate AI test, highlighting its use in identifying biochemical recurrence after prostatectomy. This AI model, validated with data from key trials, not only distinguishes patients based on the aggressiveness of their disease but...
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- Zach Klaassen discusses with Todd Morgan about innovative post-prostatectomy biomarkers. Dr. Morgan presents findings on a new AI model developed by ArteraAI for assessing biochemical recurrence in prostate cancer patients post-prostatectomy. This model, validated using clinical data and digital pathology from two significant trials, shows high predictive accuracy. It aims to distinguish patients...
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- Rana McKay discusses her team’s study on the HSD3B1 gene and its link to prostate cancer outcomes, published in JAMA Network Open. The study focuses on the adrenal-permissive allele of HSD3B1, which influences the body's conversion of DHEA to potent androgens, affecting responses to hormonal therapy and prostate cancer progression. Dr. McKay explains that this genetic variant shows variable preval...
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