Escherichia coli and Proteus mirabilis are important urinary tract pathogens.
The constant increase in the antibiotic resistance of clinical bacterial strains has become an important clinical problem. The aim of this study was to compare the antibiotic resistance of 141 clinical (Sweden and Poland) and 42 laboratory (Czech Republic) P. mirabilis strains and 129 clinical (Poland) uropathogenic E. coli strains. The proportion of unique versus diverse patterns in Swedish clinical and laboratory P. mirabilis strain collections was comparable. Notably, a similar proportion of unique versus diverse patterns was observed in Polish clinical P. mirabilis and E. coli strain collections. Mathematical models of the antibiotic resistance of E. coli and P. mirabilis strains based on Kohonen networks and association analysis are presented. In contrast to the three clinical strain collections, which revealed complex associations with the antibiotics tested, laboratory P. mirabilis strains provided simple antibiotic association diagrams. The monitoring of antibiotic resistance patterns of clinical E. coli and P. mirabilis strains plays an important role in the treatment procedures for urinary tract infections and is important in the context of the spreading drug resistance in uropathogenic strain populations. The adaptability and flexibility of the genomes of E. coli and P. mirabilis strains are discussed.
Written by:
Adamus-Bialek W, Zajac E, Parniewski P, Kaca W. Are you the author?
Department of Environment Protection and Modelling, Jan Kochanowski University, 15 Swietokrzyska Street, 25-406 Kielce, Poland.
Reference: Mol Biol Rep. 2013 Apr;40(4):3429-35.
doi: 10.1007/s11033-012-2420-3
PubMed Abstract
PMID: 23283741
UroToday.com Infections Section
