Upper Tract Urothelial Carcinoma COE

UGN-101 in Upper Tract Urothelial Cancer: Real-World Data Analysis - Joseph Jacob

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Sam Chang interviews Joseph Jacob about a registry trial examining the effectiveness of Jelmyto (UGN-101) in treating ureteral tumors. Dr. Jacob presents data from a retrospective study involving 23 patients across 15 high-volume centers in the US. The study explores the use of Jelmyto beyond its initial indication in renal pelvis tumors, focusing on its application in ureteral tumors. Dr. Jacob r...

Early Bladder Recurrence Common in UTUC Patients Post-Nephroureterectomy Despite BCG Treatment - Paul Crispen

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Sam Chang host Paul Crispen to discuss his study on BCG efficacy in patients with upper tract urothelial carcinoma following nephroureterectomy. Dr. Crispen discusses the findings, which show that patients with a history of upper tract disease experience bladder tumor recurrences sooner than those with primary bladder tumors, despite similar overall recurrence rates. The study reveals a higher ris...

FGFR3 Inhibition for Upper Tract Urothelial Cancer: Phase 1b Trial Results - Surena Matin

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Sam Chang interviews Surena Matin about a phase 1b trial evaluating FGFR3 inhibition in localized upper tract urothelial carcinoma (UTUC). Dr. Matin discusses the study's rationale, design, and results, highlighting the high prevalence of FGFR3 mutations in UTUC and the need for better management strategies. The trial demonstrates that FGFR inhibition with infigratinib is well-tolerated and rapidl...

ENLIGHTED Trial: New Promising Approach for Low-Grade Upper Tract Urothelial Carcinoma - Vitaly Margulis

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Zach Klaassen welcomes Vitaly Margulis to discuss the ENLIGHTED trial, a phase three study addressing low-grade upper tract urothelial carcinoma. Dr. Margulis explains the necessity of the trial by highlighting the common over-treatment of this cancer type due to the limited and challenging endoscopic management options available. The trial focuses on Vascular Targeted Photodynamic therapy (VTP),...

Advancing UTUC Diagnosis: Protein-Based Biomarker Test Outperforms Cytology - Hideki Furuya

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Hideki Furuya presents promising findings on a new urine test, Oncuria-Detect, for diagnosing upper tract urothelial carcinoma (UTUC). Given that UTUC is a rare cancer often difficult to detect early, this non-invasive test is a significant advancement. Oncuria-Detect, originally developed for bladder cancer, measures ten biomarkers associated with urothelial cancers. Dr. Furuya's study, involving...

POUT Trial: Final Results of Adjuvant Chemotherapy in Upper Tract Urothelial Carcinoma - Alison Birtle

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Sam Chang hosts Alison Birtle to discuss the final results of the POUT trial for upper tract urothelial carcinoma. Dr. Birtle highlights the trial's significance, conducted across 75 UK centers and supported by Cancer Research UK, emphasizing the involvement of patients and their families. The study, addressing an unmet need in UTUC, compared adjuvant chemotherapy with surveillance, showing signif...

Predictive Biomarkers for Upper Tract Urothelial Carcinoma - Helen Hougen

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Sam Chang converses with Helen Hougen about her presentation on predictive biomarkers for upper tract urothelial carcinoma (UTUC) at the SUO, emphasizing their critical role in risk stratification. They delve into the limitations of current diagnostic tools like ureteroscopic biopsies, which often provide imperfect information and pose significant patient burdens. Highlighting the promise of minim...

Route of Administration for UGN-101 and the Impact on Oncological & Safety Outcomes - Jennifer Linehan

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Sam Chang engages with Jennifer Linehan to discuss topical chemotherapy for upper tract urothelial carcinoma, particularly utilizing UGN-101 (Jelmyto). Dr. Linehan shares her invaluable insights and experiences, primarily from the OLYMPUS trial, highlighting the evolution in administration methods for UGN-101, transitioning from retrograde to the more convenient antegrade approach via a nephrostom...

What Every Urologist Should Know About UGN-101 Treatment and its Real-World Implications for Urothelial Cancer - Hristos Kaimakliotis

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Sam Chang engages in a detailed discussion with Hristos Kaimakliotis, who presents findings from a multi-institutional review he authored, focusing on real-world practices with Jelmyto, a treatment for upper tract urothelial cancer. The study explores the efficacy of mitomycin reverse thermal gel, UGN-101, which has shown promise in ablating low-grade upper tract urothelial cancer. The OLYMPUS tri...

Guidelines and Real-World Scenarios in Upper Tract Urothelial Carcinoma Treatment - Kyle Rose

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In a case presentation, Zach Klaassen and Kyle Rose discuss the complexities of treating low-grade upper tract urothelial carcinoma. Dr. Rose presents a case of a 69-year-old male patient with the condition, emphasizing the importance of thorough workup and staging. The discussion covers the challenges of accurate biopsy sampling and the potential for under-staging or over-staging patients. Dr. Ro...