Upper Tract Urothelial Carcinoma COE - Results from #60

Upper Tract Urothelial Carcinoma COE

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SAUL Trial Data: Real World Experience of Atezolizumab in Carcinomas of the Urinary Tract- Cora Sternberg Details Cora Sternberg, MD, and Alicia Morgans, MD discuss the SAUL (A Study of Atezolizumab in Locally Advanced or Metastatic Urothelial or Non-Urothelial Carcinoma of the Urinary Tract) trial data which represents the "real world" experience with atezolizumab for the treatment of carcinomas of the urinary tract. The SAUL study enrolled patients that typically would be excluded from clinical trials inclu...
Systemic Therapies in Upper Tract Urothelial Carcinoma - Srikala Sridhar Details Kala Sridhar provides a state of the-state in the contemporary understanding of upper tract disease, recent clinical trial findings and the impact of those trials on clinical practice treatment. Upper tract urothelial cancer (UTUC) accounts for approximately 5 - 7% of all urothelial cancers. At presentation about 60% of patients demonstrate invasive and/or locally advanced disease compared to abou...
Challenges in the Diagnosis and Treatment of UTUC - Peter Black Details Peter Black, MD discusses the challenges in both the diagnosis and treatment of UTUC. First, Dr. Black mentions the difficulty in obtaining adequate tissue for confirmation of diagnosis and to risk stratify patients. Traditionally diagnosis has been made based on imaging alone due to the challenges with obtaining biopsies leading to overtreatment for many patients. Due to the inability to appropri...
Challenges in Immunotherapy for Bladder Cancer- Maria De Santis Details Maria De Santis discusses challenges in immunotherapy approaches for urothelial cancer with Alicia Morgans. One of the key challenges is understanding if the clinical trial data is translatable in daily practice due to the fact that most patients presenting with urothelial cancer are elderly. These patients tend to be over 70 years of age, have impaired renal function and decreased performance sta...
The Diagnostic and Therapeutic Challenges Associated with UTUC - Sam Chang Details Alicia Morgans and Sam Chang discuss the diagnostic and therapeutic challenges of upper tract urothelial carcinoma (UTUC). UTUC is relatively uncommon compared to urothelial carcinoma, accounting for 5-7% of all cases. The disease can be quite insidious and present a challenge to diagnose. Dr. Chang discusses the use of CT urograms in the diagnosis and how size, grade, and stage of the tumor is us...