To describe oncological and functional outcomes in patients treated with reconstructive organ-sparing surgery (OSS) for squamous cell carcinoma of the penis. Plastic reconstructive OSS of the penis with a split thickness skin graft (STSG) has been proposed as a treatment option for penile cancer, with the objective being preservation of physiological voiding and sexual function without comprising oncological control.
Multicenter study reporting clinicopathological data of 57 patients with malignant lesions of the penis treated with OSS and plastic reconstructive surgery with STSG from 2007 to 2019. Health related quality of life (HRQoL) was assessed with EuroQoL-5D-3L, urinary symptoms with the ICIQ-MLUTS and erectile function with the IIEF-5.
Fifty-seven patients underwent OSS reconstructive surgery. Twenty underwent glans resurfacing, 23 partial penectomy and 14 glansectomy Median age was 55.1 years (IQR 29-90), median follow up 55.7 months (3-149). At the time of data analysis 6 patients had died of SCC (12.5%) and 10 (17.8%) had progressed. Kaplan-Meier estimates showed a 5-year survival rate of 87.5% and a 5-year PFS of 83%. We assessed HRQoL and functional outcomes in 32 patients. EuroQol 5D-3L showed a mean health status of 82.5%, median Voiding score (VS) of the ICIQ-MLTUS was 4 (IQR 1-15) and median IIEF-5 19 (IQR 10.75-25).
OSS of the penis remains a safe and viable option for the treatment of SCC, ensuring a favorable appearance of the penis, preserving urinary and sexual function, with good HRQoL and without comprising oncological safety in selected cases.
Urology. 2020 May 04 [Epub ahead of print]
Jaime Pérez, Julián Chavarriaga, Ana Ortiz, Paola Orrego, Sandra Rueda, William Quiroga, Nicolás Fernandez, German Patiño, Verónica Tobar, Nicolás Villareal, Juan Prada, Catalina Barco, Guillermo Sarmiento
Division of Urology, Hospital Universitario San Ignacio. Pontificia Universidad Javeriana. Bogotá, Colombia. Carrera 7 # 40-62; Department of Urology. Fundación Santa Fe de Bogotá. Colombia. Carrera 7 # 117-15. Electronic address: ., Division of Urology, Hospital Universitario San Ignacio. Pontificia Universidad Javeriana. Bogotá, Colombia. Carrera 7 # 40-62. Electronic address: ., Division of Urology. Fundación Oftalmológica de Santander Clínica Ardila Lulle (FOSCAL), Universidad Autonoma de Bucaramanga. Colombia. Av. Gonzalez Valencia # 54-49. Electronic address: ., Division of Urology. Hospital Militar Central, Universidad Militar Nueva Granada. Bogotá, Colombia. Tv. 3C # 49-02. Electronic address: ., Division of Urology. Fundación Oftalmológica de Santander Clínica Ardila Lulle (FOSCAL), Universidad Autonoma de Bucaramanga. Colombia. Av. Gonzalez Valencia # 54-49. Electronic address: ., Division of Urology. Hospital Militar Central, Universidad Militar Nueva Granada. Bogotá, Colombia. Tv. 3C # 49-02. Electronic address: ., Division of Urology, Hospital Universitario San Ignacio. Pontificia Universidad Javeriana. Bogotá, Colombia. Carrera 7 # 40-62; Department of Urology. Fundación Santa Fe de Bogotá. Colombia. Carrera 7 # 117-15; Division of Urology. Hospital for SickKids. University of Toronto. Canada. 555 University Ave, Toronto, ON M5G. Electronic address: ., Division of Urology, Hospital Universitario San Ignacio. Pontificia Universidad Javeriana. Bogotá, Colombia. Carrera 7 # 40-62. Electronic address: ., Division of Urology. Fundación Oftalmológica de Santander Clínica Ardila Lulle (FOSCAL), Universidad Autonoma de Bucaramanga. Colombia. Av. Gonzalez Valencia # 54-49. Electronic address: ., Division of Urology, Hospital Universitario San Ignacio. Pontificia Universidad Javeriana. Bogotá, Colombia. Carrera 7 # 40-62. Electronic address: ., Division of Urology, Hospital Universitario San Ignacio. Pontificia Universidad Javeriana. Bogotá, Colombia. Carrera 7 # 40-62. Electronic address: ., Department of Urology. Fundación Santa Fe de Bogotá. Colombia. Carrera 7 # 117-15. Electronic address: ., Division of Urology. Fundación Oftalmológica de Santander Clínica Ardila Lulle (FOSCAL), Universidad Autonoma de Bucaramanga. Colombia. Av. Gonzalez Valencia # 54-49. Electronic address: .
PubMed http://www.ncbi.nlm.nih.gov/pubmed/32380155