The incidence of penile cancer varies by ethnicity, and is not well described among Chinese patients.
We performed a retrospective study to assess the prognostic factors in Chinese patients with penile invasive Squamous cell carcinoma (iSCC). We reviewed the medical records of 83 consecutive patients treated at our institution. The Kaplan-Meier method and log-rank test and multivariate Cox proportional hazard models were used to identify the prognostic factors predicting for cancer specific survival (CSS). Univariate and multivariate logistical regression analysis were used to analyze the predictive factors for lymph node metastasis (LNM). A total of 55 patients were followed. Thirteen patients (23.6%) died from the disease during follow up. By univariate analysis, older age (≥49yr, p=0.048), radical resection (compared with local/partial resection, p=0.040), high histological grade (p=0.037) and lymph node metastasis (p< 0.001) were each associated with poor prognosis. By multivariate analysis, chronological age (p=0.011) and lymph node metastasis (p=0.002) were independent prognostic factors. High histological grade (p=0.003) was an independent predictive factor for lymph node metastasis. In our series, chronological age and lymph node metastasis were independent prognostic factors for CSS. The histological grade, not the tumor stage, was still an influential predictive factor of LNM of in Chinese patients with penile iSCC.
Written by:
Chen X, Li X, Garcia MM, Gong K, Song Y, He Z, Zhou L. Are you the author?
Reference: J Androl. 2012 Jun 28. Epub ahead of print.
doi: 10.2164/jandrol.112.016378
PubMed Abstract
PMID: 22744863
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